Maintenance of independence in old age depends, in part, on lower extremity function. Lean mass and strength both contribute to lower extremity function. Although the term sarcopenia suggests that muscle mass is the key factor, interventions on strength alone, rather than on mass alone, have been more effective in reversing disability. This project is multifaceted and is conducted through collaboration with several extramural investigators. It includes work with the Sarcopenia Initiative with the NIH Foundation, analysis of factors that might accelerate or prevent loss of lean mass, and projects focused on hypertrophy of muscle and change in fatty infiltration with interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG004050-06
Application #
8736685
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$91,841
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
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Murphy, Rachel A; Ip, Edward H; Zhang, Qiang et al. (2014) Transition to sarcopenia and determinants of transitions in older adults: a population-based study. J Gerontol A Biol Sci Med Sci 69:751-8
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McLean, Robert R; Shardell, Michelle D; Alley, Dawn E et al. (2014) Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci 69:576-83
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