The success of genetic epidemiology lies in replication of results, and in joining with other cohorts to boost statistical power. To that end, this project draws on the AGES-Reykjavik Study and Health, Aging, and Body Composition (Health ABC) Study, both of which have been involved in candidate gene studies and have completed genome-wide association studies (GWAS). Genotypes from both studies have been imputed to 2.5 million SNPs from the international HapMap Project and further imputed to the 1,000 Genomes panel which yields approximatelyl 8.5 million SNPs. A variety of exome regions have also been genotyped using chip technology. AGES-Reykjavik and Health ABC share several phenotypes in common - measurement of adipose tissue, muscle area, muscle density, measures of grip and quadricep strength, assessment of physical functioning, and numerous other aging-related phenotypes. All analysis for these bone and body composition traits will be done as a collaboration between AGES-Reykjavik and the Health ABC Studies. We will join the results in a meta-analysis and consider joining with consortia of other epidemiologic GWAS to further support or refute our findings. Both the AGES-Reykjavik and Health ABC Studies participate in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Institute on Aging
Zip Code
Nielson, Carrie M; Liu, Ching-Ti; Smith, Albert V et al. (2016) Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. J Bone Miner Res :
Okbay, Aysu; Baselmans, Bart M L; Neve, Jan-Emmanuel De et al. (2016) Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet 48:970
Liu, Chunyu; Kraja, Aldi T; Smith, Jennifer A et al. (2016) Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet :
Postmus, Iris; Warren, Helen R; Trompet, Stella et al. (2016) Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. J Med Genet :
Hsu, Yi-Hsiang; Li, Guo; Liu, Ching-Ti et al. (2016) Targeted Sequencing of Genome Wide Significant Loci Associated with Bone Mineral Density (BMD) Reveals Significant Novel and Rare Variants: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Hum Mol Genet :
van Leeuwen, Elisabeth M; Sabo, Aniko; Bis, Joshua C et al. (2016) Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. J Med Genet 53:441-9
Dehghan, Abbas; Bis, Joshua C; White, Charles C et al. (2016) Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium. PLoS One 11:e0144997
Roberts, Jason D; Hu, Donglei; Heckbert, Susan R et al. (2016) Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals. JAMA Cardiol 1:442-50
Katzman, Shana M; Strotmeyer, Elsa S; Nalls, Michael A et al. (2015) Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly. J Gerontol A Biol Sci Med Sci 70:1400-8
Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David et al. (2014) Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet 23:3054-68

Showing the most recent 10 out of 57 publications