Research on various aspects of Giardia lamblia is limited. Most studies are collaborative in nature. Using a model of Giardia infection developed in this lab and based on earlier studies performed at NIH, Steve Singer's and his lab show that Il-6, which is important in control of infection in mice is not produced by T cells but by dendritic cells. We have completed genomic sequencing of isolates GS( genotype B) and DH( genotype A2) and compared theme to a draft sequence of GS and the previously published sequence of WB. THe results show that GS is very different from WB and DH and strongly suggests it is a different species.

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Nash, Theodore E (2013) Unraveling how Giardia infections cause disease. J Clin Invest 123:2346-7
Adam, Rodney D; Dahlstrom, Eric W; Martens, Craig A et al. (2013) Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of genotypes A1 and E (WB and Pig). Genome Biol Evol 5:2498-511
Kamda, Joel D; Nash, Theodore E; Singer, Steven M (2012) Giardia duodenalis: dendritic cell defects in IL-6 deficient mice contribute to susceptibility to intestinal infection. Exp Parasitol 130:288-91
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