Accomplishments during the year: 1. The immune response to AMA1, RON2 and EBA-175 has been studied. This work continues to expand our understanding of parasite invasion of red cells by identifying the receptors and ligands and determining the potential of these targets for vaccine development. 2. The knockout of a PfSET gene (named PfSETVS) leads to expression of all var genes, indicating that PfSETvs silences var genes. 3. Plasmodium development in the mosquito. 4. We have identified some small molecules that block junction formation and invasion.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
Gunalan, Karthigayan; Lo, Eugenia; Hostetler, Jessica B et al. (2016) Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans. Proc Natl Acad Sci U S A 113:6271-6
Gordon, Emile B; Hart, Geoffrey T; Tran, Tuan M et al. (2015) Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proc Natl Acad Sci U S A 112:13075-80
Draper, Simon J; Angov, Evelina; Horii, Toshihiro et al. (2015) Recent advances in recombinant protein-based malaria vaccines. Vaccine 33:7433-43
Srinivasan, Prakash; Ekanem, Emmanuel; Diouf, Ababacar et al. (2014) Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria. Proc Natl Acad Sci U S A 111:10311-6
Crompton, Peter D; Moebius, Jacqueline; Portugal, Silvia et al. (2014) Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annu Rev Immunol 32:157-87
Desai, Sanjay A; Miller, Louis H (2014) Malaria: Protein-export pathway illuminated. Nature 511:541-2
Miller, Louis H; Ackerman, Hans C; Su, Xin-zhuan et al. (2013) Malaria biology and disease pathogenesis: insights for new treatments. Nat Med 19:156-67
Knockel, Julia; Molina-Cruz, Alvaro; Fischer, Elizabeth et al. (2013) An impossible journey? The development of Plasmodium falciparum NF54 in Culex quinquefasciatus. PLoS One 8:e63387
Zhu, Daming; Qian, Feng; Wu, Yimin et al. (2013) Determination of protein concentration for protein-protein conjugates using ultraviolet absorption. J Immunol Methods 387:317-21
Jiang, Lubin; Mu, Jianbing; Zhang, Qingfeng et al. (2013) PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature 499:223-7

Showing the most recent 10 out of 54 publications