Our research project focuses on how malaria parasites become resistant to major antimalarial drugs and why strains of the two species responsible most human malaria disability and death (Plasmodium falciparum and Plasmodium vivax) show different infectivities to humans and other primates. In these areas of research, we seek advances that can improve the knowledge of disease processes in malaria and thereby support the development or testing of new antimalarial chemotherapies, diagnostic tools, and vaccines. The research activities in our program are multidisciplinary and include field studies in malarious regions of Africa, Asia and South America, as well as programs of basic laboratory investigation.

Project Start
Project End
Budget Start
Budget End
Support Year
28
Fiscal Year
2013
Total Cost
$1,349,261
Indirect Cost
City
State
Country
Zip Code
Moraes Barros, Roberto R; Straimer, Judith; Sa, Juliana M et al. (2015) Editing the Plasmodium vivax genome, using zinc-finger nucleases. J Infect Dis 211:125-9
Furuya, Tetsuya; Sá, Juliana M; Chitnis, Chetan E et al. (2014) Reticulocytes from cryopreserved erythroblasts support Plasmodium vivax infection in vitro. Parasitol Int 63:278-84
Tokumasu, Fuyuki; Crivat, Georgeta; Ackerman, Hans et al. (2014) Inward cholesterol gradient of the membrane system in P. falciparum-infected erythrocytes involves a dilution effect from parasite-produced lipids. Biol Open 3:529-41
Kone, Aminatou; Mu, Jianbing; Maiga, Hamma et al. (2013) Quinine treatment selects the pfnhe-1 ms4760-1 polymorphism in Malian patients with Falciparum malaria. J Infect Dis 207:520-7
Lopera-Mesa, Tatiana M; Doumbia, Saibou; Chiang, Serena et al. (2013) Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity. J Infect Dis 207:1655-63
Hayton, Karen; Dumoulin, Peter; Henschen, Bruce et al. (2013) Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats. Mol Biochem Parasitol 187:103-10
Miller, Louis H; Ackerman, Hans C; Su, Xin-zhuan et al. (2013) Malaria biology and disease pathogenesis: insights for new treatments. Nat Med 19:156-67
Nkrumah, Louis J; Riegelhaupt, Paul M; Moura, Pedro et al. (2009) Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol Biochem Parasitol 165:122-31