Our research project focuses on how malaria parasites become resistant to major antimalarial drugs and why strains of the two species responsible most human malaria disability and death (Plasmodium falciparum and Plasmodium vivax) show different infectivities to humans and other primates. In these areas of research, we seek advances that can improve the knowledge of disease processes in malaria and thereby support the development or testing of new antimalarial chemotherapies, diagnostic tools, and vaccines. The research activities in our program are multidisciplinary and include field studies in malarious regions of Africa, Asia and South America, as well as programs of basic laboratory investigation.

Project Start
Project End
Budget Start
Budget End
Support Year
28
Fiscal Year
2013
Total Cost
$1,349,261
Indirect Cost
City
State
Country
Zip Code
Shah, Shivang S; Rockett, Kirk A; Jallow, Muminatou et al. (2016) Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria. Malar J 15:13
Kite, Whitney A; Melendez-Muniz, Viviana A; Moraes Barros, Roberto R et al. (2016) Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity. Malar J 15:94
Miles, Alistair; Iqbal, Zamin; Vauterin, Paul et al. (2016) Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum. Genome Res 26:1288-99
Baniecki, Mary Lynn; Faust, Aubrey L; Schaffner, Stephen F et al. (2015) Development of a single nucleotide polymorphism barcode to genotype Plasmodium vivax infections. PLoS Negl Trop Dis 9:e0003539
Hayakawa, Eri H; Tokumasu, Fuyuki; Usukura, Jiro et al. (2015) Imaging of the subsurface structures of ""unroofed"" Plasmodium falciparum-infected erythrocytes. Exp Parasitol 153:174-9
Gadalla, Nahla B; Tavera, Gloria; Mu, Jianbing et al. (2015) Prevalence of Plasmodium falciparum anti-malarial resistance-associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to introduction of artemisinin combination therapy. Malar J 14:129
Moraes Barros, Roberto R; Straimer, Judith; Sa, Juliana M et al. (2015) Editing the Plasmodium vivax genome, using zinc-finger nucleases. J Infect Dis 211:125-9
Shah, Shivang S; Macharia, Alex; Makale, Johnstone et al. (2014) Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya. BMC Med Genet 15:93
Furuya, Tetsuya; Sá, Juliana M; Chitnis, Chetan E et al. (2014) Reticulocytes from cryopreserved erythroblasts support Plasmodium vivax infection in vitro. Parasitol Int 63:278-84
Tokumasu, Fuyuki; Crivat, Georgeta; Ackerman, Hans et al. (2014) Inward cholesterol gradient of the membrane system in P. falciparum-infected erythrocytes involves a dilution effect from parasite-produced lipids. Biol Open 3:529-41

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