The Caliciviridae are a family of positive-strand RNA viruses and consist of five genera designated: (1) Norovirus (with species Norwalk virus);(2) Sapovirus (with species Sapporo virus);(3) Vesivirus (with species, feline calicivirus and vesicular exanthema of swine virus);(4) Lagovirus (with species rabbit hemorrhagic disease virus and European brown hare syndrome virus) and (5) Nebovirus (with species Newbury-2 virus). Norwalk virus is the prototype strain for the genus Norovirus and was discovered by LID researchers in 1972. The noroviruses are the major cause of nonbacterial epidemic gastroenteritis that occurs in family, school, institutional, or community-wide outbreaks, affecting all age groups. The noroviruses are also an important cause of sporadic, acute gastroenteritis in infants and young children. The human noroviruses are genetically diverse and cannot be grown in cell culture, which has been a continuing research obstacle.

Project Start
Project End
Budget Start
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Support Year
10
Fiscal Year
2010
Total Cost
$1,815,325
Indirect Cost
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Santiana, Marianita; Ghosh, Sourish; Ho, Brian A et al. (2018) Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission. Cell Host Microbe 24:208-220.e8
Daniel-Wayman, Shelby; Fahle, Gary; Palmore, Tara et al. (2018) Norovirus, astrovirus, and sapovirus among immunocompromised patients at a tertiary care research hospital. Diagn Microbiol Infect Dis 92:143-146
Green, Kim Y (2018) Norovirus surveillance comes of age: the impact of NoroNet. Lancet Infect Dis 18:482-483
Levenson, Eric A; Martens, Craig; Kanakabandi, Kishore et al. (2018) Comparative Transcriptomic Response of Primary and Immortalized Macrophages to Murine Norovirus Infection. J Immunol 200:4157-4169
Tin, Christine M; Yuan, Lijuan; Dexter, Rachel J et al. (2017) A Luciferase Immunoprecipitation System (LIPS) assay for profiling human norovirus antibodies. J Virol Methods 248:116-129
Sosnovtsev, Stanislav V; Sandoval-Jaime, Carlos; Parra, Gabriel I et al. (2017) Identification of Human Junctional Adhesion Molecule 1 as a Functional Receptor for the Hom-1 Calicivirus on Human Cells. MBio 8:
Cotton, Ben T; Hyde, Jennifer L; Sarvestani, Soroush T et al. (2017) The Norovirus NS3 Protein Is a Dynamic Lipid- and Microtubule-Associated Protein Involved in Viral RNA Replication. J Virol 91:
Johnson, J A; Parra, G I; Levenson, E A et al. (2017) A large outbreak of acute gastroenteritis in Shippensburg, Pennsylvania, 1972 revisited: evidence for common source exposure to a recombinant GII.Pg/GII.3 norovirus. Epidemiol Infect 145:1591-1596
Sharma, Sumit; Carlsson, Beatrice; Czakó, Rita et al. (2017) Human Sera Collected between 1979 and 2010 Possess Blocking-Antibody Titers to Pandemic GII.4 Noroviruses Isolated over Three Decades. J Virol 91:
Di Martino, Barbara; Di Profio, Federica; Melegari, Irene et al. (2017) Seroprevalence for norovirus genogroup II, IV and VI in dogs. Vet Microbiol 203:68-72

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