Our research program focuses on five subject areas: (1) the nature of protection against malaria that is conferred to individuals carrying red blood cell (RBC) polymorphisms including hemoglobin C, hemoglobin S, hemoglobin E, alpha-thalassemia and G6PD deficiency;(2) the nature of naturally-acquired immunity to malaria and how it is influenced by RBC polymorphisms;(3) the molecular mechanisms by which RBC polymorphisms reduce the expression of PfEMP1, the main virulence factor of Plasmodium falciparum, on the surface of parasitized RBCs;(4) the contributions of parasite genetic and host immune factors to the clearance of P. falciparum-infected RBCs in patients treated with the antimalarial drug artesunate;and (5) the nature of the selective invasion of reticulocytes by Plasmodium vivax. In each of these areas we seek research advances that can improve the knowledge of disease processes and antimalarial drug resistance mechanisms in patients with malaria and thereby support the development of new antimalarial therapeutics and vaccines that aim to prevent illness and death. The research activities in our program are multidisciplinary and include four field studies in malarious regions of Africa and Southeast Asia as well as programs of basic laboratory investigation at NIH-sponsored laboratories in Mali and Cambodia.

Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2013
Total Cost
$992,443
Indirect Cost
City
State
Country
Zip Code
Fairhurst, Rick M; Dondorp, Arjen M (2016) Artemisinin-Resistant Plasmodium falciparum Malaria. Microbiol Spectr 4:
França, Camila T; Hostetler, Jessica B; Sharma, Sumana et al. (2016) An Antibody Screen of a Plasmodium vivax Antigen Library Identifies Novel Merozoite Proteins Associated with Clinical Protection. PLoS Negl Trop Dis 10:e0004639
Diakite, Mahamadou; Miura, Kazutoyo; Diouf, Ababacar et al. (2016) Hematological Indices in Malian Children Change Significantly During a Malaria Season and with Increasing Age: Implications for Malaria Epidemiological Studies. Am J Trop Med Hyg 95:368-72
Amaratunga, Chanaki; Lim, Pharath; Suon, Seila et al. (2016) Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study. Lancet Infect Dis 16:357-65
Pearson, Richard D; Amato, Roberto; Auburn, Sarah et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax. Nat Genet 48:959-64
St Laurent, Brandyce; Miller, Becky; Burton, Timothy A et al. (2016) Corrigendum: Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa. Nat Commun 7:10345
St Laurent, Brandyce; Miller, Becky; Burton, Timothy A et al. (2015) Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa. Nat Commun 6:8614
Fogarty, Colin B; Fay, Michael P; Flegg, Jennifer A et al. (2015) Bayesian hierarchical regression on clearance rates in the presence of ""lag"" and ""tail"" phases with an application to malaria parasites. Biometrics 71:751-9
Bustos-Arriaga, José; Mita-Mendoza, Neida K; Lopez-Gonzalez, Moises et al. (2015) Soluble mediators produced by the crosstalk between microvascular endothelial cells and dengue-infected primary dermal fibroblasts inhibit dengue virus replication and increase leukocyte transmigration. Immunol Res :
Ndour, Papa Alioune; Lopera-Mesa, Tatiana M; Diakité, Seidina A S et al. (2015) Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria. J Infect Dis 211:290-7

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