Abstract

We are interested in how bacteria and bacterial products shape the development of subsequent innate and adaptive immune responses with the goal of understanding how these host-microbe interactions influence pathogenesis of infections, autoimmunity, allergy, and cancer. In 2016-2017, we have continued our focus on host defense against the bacterial pathogen Staphylococcus aureus, uncovering the role of innate and adaptive immune pathways in mediating protective and detrimental responses to infection using mouse models, and characterizing these responses in human clinical studies. In addition, we have identified influences of host-commensal interactions on susceptibility to infections and immune responses. With these studies we have enhanced our understanding of the mechanisms controlling skin and mucosal host defense and identified potential pathways that can be targeted to enhance efficacy of vaccines and therapies against cancer, infection, and immune-mediated diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001043-10
Application #
9566677
Study Section
Project Start
Project End
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Budget End
Support Year
10
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
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  Publications

Myles, Ian A; Earland, Noah J; Anderson, Erik D et al. (2018) First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis. JCI Insight 3:
Karauzum, Hatice; Haudenschild, Christian C; Moore, Ian N et al. (2017) Lethal CD4 T Cell Responses Induced by Vaccination Against Staphylococcus aureus Bacteremia. J Infect Dis 215:1231-1239
Sastalla, Inka; Williams, Kelli W; Anderson, Erik D et al. (2017) Molecular Typing of Staphylococcus aureus Isolated from Patients with Autosomal Dominant Hyper IgE Syndrome. Pathogens 6:
Gough, Portia; Ganesan, Sundar; Datta, Sandip K (2017) IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function. J Immunol 198:4373-4382
Karauzum, Hatice; Datta, Sandip K (2017) Adaptive Immunity Against Staphylococcus aureus. Curr Top Microbiol Immunol 409:419-439
Myles, Ian A; Zhao, Ming; Nardone, Glenn et al. (2016) CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells. J Leukoc Biol :
Myles, Ian A; Williams, Kelli W; Reckhow, Jensen D et al. (2016) Transplantation of human skin microbiota in models of atopic dermatitis. JCI Insight 1:
Myles, Ian A; Reckhow, Jensen D; Williams, Kelli W et al. (2016) A method for culturing Gram-negative skin microbiota. BMC Microbiol 16:60
Drummond, Rebecca A; Collar, Amanda L; Swamydas, Muthulekha et al. (2015) CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathog 11:e1005293
Pincus, Nathan B; Reckhow, Jensen D; Saleem, Danial et al. (2015) Strain Specific Phage Treatment for Staphylococcus aureus Infection Is Influenced by Host Immunity and Site of Infection. PLoS One 10:e0124280

Showing the most recent 10 out of 24 publications