The PapillomaVirus Episteme (PaVE) has been established to provide information and bioinformatics resources to the scientific community for research on the Papillomaviridae family of viruses. The PaVE consists of a relational database and web applications that support the storage, annotation, analysis, and exchange of information. PAVE can be found at http://pave.niaid.nih.gov PaVe contains genomic and protein sequences for all papillomaviruses. It includes a multiple sequence alignment tool, a protein structure viewer, a viral typing tool and an Image viewer for visualizing clinical manifestations of viral infection. Linked review articles provided detailed information about all aspects of functional genomics of papillomaviruses.

Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$60,385
Indirect Cost
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State
Country
Zip Code
Buck, Christopher B; Van Doorslaer, Koenraad; Peretti, Alberto et al. (2016) The Ancient Evolutionary History of Polyomaviruses. PLoS Pathog 12:e1005574
Van Doorslaer, Koenraad (2013) Evolution of the Papillomaviridae. Virology :
McBride, Alison A (2013) The papillomavirus E2 proteins. Virology 445:57-79
Van Doorslaer, Koenraad; Tan, Qina; Xirasagar, Sandhya et al. (2013) The Papillomavirus Episteme: a central resource for papillomavirus sequence data and analysis. Nucleic Acids Res 41:D571-8
Lambert, Paul F; McBride, Alison; Ulrich Bernard, Hans (2013) Special issue: The Papillomavirus Episteme. Virology :
Buck, Christopher B; Phan, Giao Q; Raiji, Manish T et al. (2012) Complete genome sequence of a tenth human polyomavirus. J Virol 86:10887