In 2011, we continued our efforts to understand the impact that phenol-soluble modulins have on biofilm development. Having shown their contribution in a recent paper using S. epidermidis as model organism (Wang et al. J Clin Invest 2011), we now analyzed the contribution this peptide family has to biofilm development of S. aureus, in particular the community-associated MRSA strain USA300. Using isogenic deletion mutants in every psm gene/operon of USA300, we could show using confocal laser scanning microscopy that all PSMs contribute to biofilm maturation processes in USA300. In animal models of catheter-related infection, we demonstrated that PSMs contribute to the dissemination of USA300 biofilm-associated infection.
| Zheng, Yue; He, Lei; Asiamah, Titus K et al. (2018) Colonization of medical devices by staphylococci. Environ Microbiol 20:3141-3153 |
| Nakatsuji, Teruaki; Chen, Tiffany H; Butcher, Anna M et al. (2018) A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 4:eaao4502 |
| Le, Katherine Y; Park, Matthew D; Otto, Michael (2018) Immune Evasion Mechanisms of Staphylococcus epidermidis Biofilm Infection. Front Microbiol 9:359 |
| Da, Fei; Joo, Hwang-Soo; Cheung, Gordon Y C et al. (2017) Phenol-Soluble Modulin Toxins of Staphylococcus haemolyticus. Front Cell Infect Microbiol 7:206 |
| Otto, Michael (2017) Staphylococcus epidermidis: a major player in bacterial sepsis? Future Microbiol 12:1031-1033 |
| Nguyen, Thuan H; Park, Matthew D; Otto, Michael (2017) Host Response toStaphylococcus epidermidisColonization and Infections. Front Cell Infect Microbiol 7:90 |
| Qin, Li; Da, Fei; Fisher, Emilie L et al. (2017) Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis. PLoS Pathog 13:e1006153 |
| Qin, Li; McCausland, Joshua W; Cheung, Gordon Y C et al. (2016) PSM-Mec-A Virulence Determinant that Connects Transcriptional Regulation, Virulence, and Antibiotic Resistance in Staphylococci. Front Microbiol 7:1293 |
| Joo, Hwang-Soo; Fu, Chih-Iung; Otto, Michael (2016) Bacterial strategies of resistance to antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci 371: |
| Li, Tianming; He, Lei; Song, Yan et al. (2016) AraC-Type Regulator Rsp Adapts Staphylococcus aureus Gene Expression to Acute Infection. Infect Immun 84:723-34 |
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