Our understanding of human health and the development of new preventive and therapeutic approaches requires the integration in the study of physiology and pathology of the constant exposure of the organism to the microbiota and to evaluate physiology and pathology as states of the whole human metaorganism. In collaboration with geneticists, molecular biologists and bacteriologists, our research is conducted in a multidisciplinary manner combining, cellular immunology, microbiology and genomic approaches. Over the past fiscal year, our work further explored the role of the microbiota in the control of host immunity at barrier sites including the gut, skin and lung. Our work was the first to reveal the adjuvant role of the microbiota in the induction of protective immunity to pathogens and in the context of vaccine. Current work from our group explores the role of defined commensal species in the regulation of skin and gut immunity. In particular, our research explores the mechanism by which defined commensal species or bacterial products control tissue immune homeostasis and promote adaptive immune responses in the context of steady state, infection and tissue inflammation. Notably our work identified key antigen presenting cells responsible for the mediation of responses to commensals. In addition, our group addresses how a dysregulation in the composition of commensal populations and aberrant responses against commensals during infection can lead to pathogenic responses (e.g pathogenic consequence of infections, Crohns disease, Psoriasis). These studies are currently done in collaboration with Drs. Giorgio Trinchieri (NCI), Julie Segre (NHGR) and Karen Frank (Clinical Center). Future directions aim at further integrating patients and clinical isolates to the exploration of these questions.
| Linehan, Jonathan L; Harrison, Oliver J; Han, Seong-Ji et al. (2018) Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. Cell 172:784-796.e18 |
| Chen, Y Erin; Fischbach, Michael A; Belkaid, Yasmine (2018) Skin microbiota-host interactions. Nature 553:427-436 |
| Byrd, Allyson L; Belkaid, Yasmine; Segre, Julia A (2018) The human skin microbiome. Nat Rev Microbiol 16:143-155 |
| Ortiz, Alexandra M; Flynn, Jacob K; DiNapoli, Sarah R et al. (2018) Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques. Nat Med 24:1313-1316 |
| Belkaid, Yasmine; Harrison, Oliver J (2017) Homeostatic Immunity and the Microbiota. Immunity 46:562-576 |
| Collins, Nicholas; Belkaid, Yasmine (2017) Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? Engaging Our Endogenous Adjuvants. Cold Spring Harb Perspect Biol : |
| Byrd, Allyson L; Deming, Clay; Cassidy, Sara K B et al. (2017) Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis. Sci Transl Med 9: |
| Iwamura, Chiaki; Bouladoux, Nicolas; Belkaid, Yasmine et al. (2017) Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis. Blood 129:171-176 |
| Chudnovskiy, Aleksey; Mortha, Arthur; Kana, Veronika et al. (2016) Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell 167:444-456.e14 |
| Hand, Timothy W; Vujkovic-Cvijin, Ivan; Ridaura, Vanessa K et al. (2016) Linking the Microbiota, Chronic Disease, and the Immune System. Trends Endocrinol Metab 27:831-843 |
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