The T lymphocyte Biology Unit was created in July of 2012, and in the past month I have worked to set up the lab. I have staffed the unit with a laboratory technician and a post-doctoral Intramural Training Award visiting fellow. I have also equipped the BSL2 and BSL3 laboratory spaces with all the necessary instrumentation. I have also written and submitted an Animal Study Proposal that accounts for all of our planned studies, and submitted HPRD documents for each of the pathogens our lab will store and use in exeriments. We expect that we will be able to begin work within the next few weeks once formal approval by the IACUC is granted.

Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2012
Total Cost
$278,062
Indirect Cost
City
State
Country
Zip Code
Barber, D L (2017) Vaccination for Mycobacterium tuberculosis infection: reprogramming CD4 T-cell homing into the lung. Mucosal Immunol 10:318-321
Sallin, Michelle A; Sakai, Shunsuke; Kauffman, Keith D et al. (2017) Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis. Cell Rep 18:3091-3104
Kamphorst, Alice O; Wieland, Andreas; Nasti, Tahseen et al. (2017) Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science 355:1423-1427
Karauzum, Hatice; Haudenschild, Christian C; Moore, Ian N et al. (2017) Lethal CD4 T Cell Responses Induced by Vaccination Against Staphylococcus aureus Bacteremia. J Infect Dis 215:1231-1239
Barber, Daniel L (2017) The Helper T Cell's Dilemma in Tuberculosis. Cell Host Microbe 21:655-656
Zhang, Yuan; Ma, Chi A; Lawrence, Monica G et al. (2017) PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients. J Exp Med 214:2523-2533
Kauffman, K D; Sallin, M A; Sakai, S et al. (2017) Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques. Mucosal Immunol :
Xie, Yingda L; Rosen, Lindsey B; Sereti, Irini et al. (2016) Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFN? Autoantibodies. Clin Infect Dis 62:770-773
Sakai, Shunsuke; Kauffman, Keith D; Sallin, Michelle A et al. (2016) CD4 T Cell-Derived IFN-? Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease. PLoS Pathog 12:e1005667
Sionov, Edward; Mayer-Barber, Katrin D; Chang, Yun C et al. (2015) Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis. PLoS Pathog 11:e1005040

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