HIV is known to replicate primarily in activated CD4+ T cells. In addition, HIV can remain silent in unactivated T cells - what is referred to as the latent reservoir. Because current anti-retroviral agents only target actively replicating virus, the existance of a latent reservoir is the primary reason why current strategies do not eliminate HIV from people. This study seeks to define the subsets of CD4+ T cells in patients that contain HIV - in both active and latent forms - as a basis to develop strategies to eliminate HIV from the body.

Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2013
Total Cost
$1,273,878
Indirect Cost
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State
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Zip Code
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Chun, Tae-Wook; Shawn Justement, J; Murray, Danielle et al. (2013) Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers. J Infect Dis :
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