HIV is known to replicate primarily in activated CD4+ T cells. In addition, HIV can remain silent in unactivated T cells - what is referred to as the latent reservoir. Because current anti-retroviral agents only target actively replicating virus, the existance of a latent reservoir is the primary reason why current strategies do not eliminate HIV from people. This study seeks to define the subsets of CD4+ T cells in patients that contain HIV - in both active and latent forms - as a basis to develop strategies to eliminate HIV from the body.

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Cooper, Arik; Garcia, Mayra; Petrovas, Constantinos et al. (2013) HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. Nature 498:376-9
Chun, Tae-Wook; Shawn Justement, J; Murray, Danielle et al. (2013) Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers. J Infect Dis :
Koup, Richard A; Lamoreaux, Laurie; Zarkowsky, David et al. (2009) Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials. J Virol 83:6318-22
Heeregrave, Edwin J; Geels, Mark J; Brenchley, Jason M et al. (2009) Lack of in vivo compartmentalization among HIV-1 infected naive and memory CD4+ T cell subsets. Virology 393:24-32
Sun, Yue; Bailer, Robert T; Rao, Srinivas S et al. (2009) Systemic and mucosal T-lymphocyte activation induced by recombinant adenovirus vaccines in rhesus monkeys. J Virol 83:10596-604
Geldmacher, Christof; Schuetz, Alexandra; Ngwenyama, Njabulo et al. (2008) Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection. J Infect Dis 198:1590-8