We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2012
Total Cost
$1,273,880
Indirect Cost
City
State
Country
Zip Code
Ferrando-Martinez, Sara; De Pablo-Bernal, Rebeca S; De Luna-Romero, Marta et al. (2017) Thymic Function Failure Is Associated With Human Immunodeficiency Virus Disease Progression. Clin Infect Dis 64:1191-1197
Coates, Emily E; Costner, Pamela J; Nason, Martha C et al. (2017) Lymph Node Activation by PET/CT Following Vaccination With Licensed Vaccines for Human Papillomaviruses. Clin Nucl Med 42:329-334
Wheatley, Adam K; Whittle, James R R; Lingwood, Daniel et al. (2015) H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem. J Immunol 195:602-10
Prentice, Heather A; Tomaras, Georgia D; Geraghty, Daniel E et al. (2015) HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition. Sci Transl Med 7:296ra112
Liang, Frank; Ploquin, Aurélie; Hernández, José DelaO et al. (2015) Dissociation of skeletal muscle for flow cytometric characterization of immune cells in macaques. J Immunol Methods 425:69-78
Francica, Joseph R; Sheng, Zizhang; Zhang, Zhenhai et al. (2015) Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization. Nat Commun 6:6565
Yamamoto, Takuya; Lynch, Rebecca M; Gautam, Rajeev et al. (2015) Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection. Sci Transl Med 7:298ra120
Petrovas, Constantinos; Koup, Richard A (2014) T follicular helper cells and HIV/SIV-specific antibody responses. Curr Opin HIV AIDS 9:235-41
Boswell, Kristin L; Paris, Robert; Boritz, Eli et al. (2014) Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection. PLoS Pathog 10:e1003853
Ferrando-Martinez, Sara; Casazza, Joseph P; Leal, Manuel et al. (2012) Differential Gag-specific polyfunctional T cell maturation patterns in HIV-1 elite controllers. J Virol 86:3667-74

Showing the most recent 10 out of 31 publications