We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
Shmagel, K V; Saidakova, E V; Shmagel, N G et al. (2016) Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection. HIV Med 17:581-9
Bonsignori, Mattia; Zhou, Tongqing; Sheng, Zizhang et al. (2016) Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell 165:449-63
Yamamoto, Takuya; Lynch, Rebecca M; Gautam, Rajeev et al. (2015) Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection. Sci Transl Med 7:298ra120
Fletcher, Courtney V; Staskus, Kathryn; Wietgrefe, Stephen W et al. (2014) Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc Natl Acad Sci U S A 111:2307-12
Calantone, Nina; Wu, Fan; Klase, Zachary et al. (2014) Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells. Immunity 41:493-502
Boswell, Kristin L; Paris, Robert; Boritz, Eli et al. (2014) Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection. PLoS Pathog 10:e1003853
Mandell, Daniel T; Kristoff, Jan; Gaufin, Thaidra et al. (2014) Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts. J Virol 88:6778-92
Hill, Brenna J; Darrah, Patricia A; Ende, Zachary et al. (2014) Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations. J Immunol 193:5626-36
Ladell, Kristin; Hashimoto, Masao; Iglesias, Maria Candela et al. (2013) A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38:425-36
Naranbhai, Vivek; Samsunder, Natasha; Sandler, Netanya G et al. (2013) Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004. J Acquir Immune Defic Syndr 63:294-8

Showing the most recent 10 out of 48 publications