We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2012
Total Cost
$304,437
Indirect Cost
City
State
Country
Zip Code
Shmagel, K V; Saidakova, E V; Shmagel, N G et al. (2016) Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection. HIV Med 17:581-9
Bonsignori, Mattia; Zhou, Tongqing; Sheng, Zizhang et al. (2016) Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell 165:449-63
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Hill, Brenna J; Darrah, Patricia A; Ende, Zachary et al. (2014) Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations. J Immunol 193:5626-36
Ladell, Kristin; Hashimoto, Masao; Iglesias, Maria Candela et al. (2013) A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38:425-36
Naranbhai, Vivek; Samsunder, Natasha; Sandler, Netanya G et al. (2013) Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004. J Acquir Immune Defic Syndr 63:294-8

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