We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2012
Total Cost
$304,437
Indirect Cost
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State
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Yamamoto, Takuya; Lynch, Rebecca M; Gautam, Rajeev et al. (2015) Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection. Sci Transl Med 7:298ra120
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Boswell, Kristin L; Paris, Robert; Boritz, Eli et al. (2014) Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection. PLoS Pathog 10:e1003853
Ladell, Kristin; Hashimoto, Masao; Iglesias, Maria Candela et al. (2013) A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38:425-36
Naranbhai, Vivek; Samsunder, Natasha; Sandler, Netanya G et al. (2013) Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004. J Acquir Immune Defic Syndr 63:294-8
Roux, Antoine; Mourin, Gisele; Fastenackels, Solene et al. (2013) CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation. Clin Immunol 148:16-26
Petrovas, Constantinos; Yamamoto, Takuya; Price, David A et al. (2013) High Production Rates Sustain In Vivo Levels of PD-1high Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance. J Virol 87:9836-44

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