HIV is known to primarily replicate in activated CD4+ T cells. In vitro studies have assessed the ability of HIV to replicate in multiple subsets of CD4+ T cells, and have identified several potential sources of T cells that are subject to infection by HIV. However, it remains unclear which CD4+ T cells are most frequently infected in vivo, and the impact of infection of these various subsets. This study seeks to define the subsets of CD4+ T cells that are naturally infected in patients, the anatomical sites of those infected cells and the impact upon HIV- and pathogen-specific immunity and the latent reservoir of HIV.

Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code
Schramm, Chaim A; Douek, Daniel C (2018) Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design. Front Immunol 9:1876
Buggert, Marcus; Nguyen, Son; Salgado-Montes de Oca, Gonzalo et al. (2018) Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue. Sci Immunol 3:
Wieland, Andreas; Kamphorst, Alice O; Adsay, N Volkan et al. (2018) T cell receptor sequencing of activated CD8 T cells in the blood identifies tumor-infiltrating clones that expand after PD-1 therapy and radiation in a melanoma patient. Cancer Immunol Immunother 67:1767-1776
Shugay, Mikhail; Bagaev, Dmitriy V; Zvyagin, Ivan V et al. (2018) VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Res 46:D419-D427
Ramesh, Akshaya; Darko, Sam; Hua, Axin et al. (2017) Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies. Front Immunol 8:1407
Breden, Felix; Luning Prak, Eline T; Peters, Bjoern et al. (2017) Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data. Front Immunol 8:1418
Afik, Shaked; Yates, Kathleen B; Bi, Kevin et al. (2017) Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state. Nucleic Acids Res 45:e148
Shmagel, K V; Saidakova, E V; Shmagel, N G et al. (2016) Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection. HIV Med 17:581-9
Lederman, Michael M; Cannon, Paula M; Currier, Judith S et al. (2016) A Cure for HIV Infection: ""Not in My Lifetime"" or ""Just Around the Corner""? Pathog Immun 1:154-164
Bonsignori, Mattia; Zhou, Tongqing; Sheng, Zizhang et al. (2016) Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell 165:449-63

Showing the most recent 10 out of 37 publications