Evaluation of the investigational vaccines in this project are part of the VRC mission related to biodefense and emerging pathogens. In FY 13 this project included clinical assessments and data analysis for clinical trials of investigational vaccines against four types of infectious diseases: filoviruses (Marburg and Ebola), influenza (avian and seasonal strains), alphaviruses (Chikungunya) and malaria. Further evaluation of vaccine approaches will continue as the VRC develops additional candidate vaccine regimens. Published results from clinical trials have included: an Ebola DNA vaccine study (VRC 204) Clin Vaccine Immunol, 2006. 13(11):1267-77; a West Nile virus DNA vaccine study (VRC 302) J Infect Dis, 2007. 196(12):1732-40, a SARS DNA vaccine study (VRC 301) Vaccine 2008 Nov 25;26(50):6338-43. a second generation West Nile virus DNA vaccine study (VRC 303) J Infect Dis, 2011, May 15;203(10). a second generation Ebola rAd5 vaccine study (VRC 205) Vaccine 2010 Oct 27. an H5N1 gene based prime, inactivated boost study (VRC 306) Lancet Infect Dis. 2011 Dec;11(12):916-24 an H5 DNA vaccine study and H5 route study (VRC 304 and VRC 305) Clin Vaccine Immunol. 2012 Nov;19(11):1792-7 a follow on H5N1 prime, inactivated boost interval examination study (VRC 310) J Infect Dis. 2013 Aug 1;208(3):413-7, J Infect Dis. 2013 Aug 1;208(3):418-22 a dose-escalation with experimental challenge to evaluate intravenous administration of PfSPZ vaccine trial (VRC 312) Science. 2013 Aug 8

Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2013
Total Cost
$851,944
Indirect Cost
City
State
Country
Zip Code
Chang, Lee-Jah; Dowd, Kimberly A; Mendoza, Floreliz H et al. (2014) Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. Lancet :
Whittle, James R R; Wheatley, Adam K; Wu, Lan et al. (2014) Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages. J Virol 88:4047-57
Mukherjee, Swati; Dowd, Kimberly A; Manhart, Carolyn J et al. (2014) Mechanism and significance of cell type-dependent neutralization of flaviviruses. J Virol 88:7210-20
Ledgerwood, Julie E; Zephir, Kathryn; Hu, Zonghui et al. (2013) Prime-boost interval matters: a randomized phase 1 study to identify the minimum interval necessary to observe the H5 DNA influenza vaccine priming effect. J Infect Dis 208:418-22
Khurana, Surender; Wu, Jian; Dimitrova, Milena et al. (2013) DNA priming prior to inactivated influenza A(H5N1) vaccination expands the antibody epitope repertoire and increases affinity maturation in a boost-interval-dependent manner in adults. J Infect Dis 208:413-7
Obara, Christopher J; Dowd, Kimberly A; Ledgerwood, Julie E et al. (2013) Impact of viral attachment factor expression on antibody-mediated neutralization of flaviviruses. Virology 437:20-7
Seder, Robert A; Chang, Lee-Jah; Enama, Mary E et al. (2013) Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science 341:1359-65
Ledgerwood, Julie E (2013) AS03-adjuvanted influenza vaccine in elderly people. Lancet Infect Dis 13:466-7
Graham, B S; Ledgerwood, J E; Nabel, G J (2009) Vaccine development in the twenty-first century: changing paradigms for elusive viruses. Clin Pharmacol Ther 86:234-6
Sullivan, Nancy J; Martin, Julie E; Graham, Barney S et al. (2009) Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule. Nat Rev Microbiol 7:393-400

Showing the most recent 10 out of 13 publications