A major focus of study during the past year has been the study of HIV-1 induced cell death at the molecular and cellular levels. The lab studied different factors to attempt to better understand T cell death during HIV infection. The results of these studies are designed to help uncover and define the mechanisms involved in CD4 T cell depletion by specific viral gene products and in the context of viral infection. Some specific gene products were identified as potentially important in this process and studies are continuing.

Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2012
Total Cost
$220,670
Indirect Cost
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State
Country
Zip Code
Cooper, Arik; Garcia, Mayra; Petrovas, Constantinos et al. (2013) HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. Nature 498:376-9