A major focus of study during the past year has been to continue to better understand HIV-1 induced cell death at the molecular and cellular levels and to test therapeutic interventions in animal models. The lab continued their ongoing studies of different factors to better understand T cell death during HIV infection. The results of these studies are designed to help uncover and define the mechanisms involved in CD4 T cell depletion by specific viral gene products and in the context of viral infection.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
Cooper, Arik; Garcia, Mayra; Petrovas, Constantinos et al. (2013) HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. Nature 498:376-9