Abstract

Escape from adaptive T-cell immunity through mutation of viral antigenic structure is a cardinal feature in the pathogenesis of SIV/HIV infection and a major obstacle to antiretroviral vaccine development. However, the molecular determinants of this phenomenon at the T-cell receptor (TCR)antigen interface are unknown. This study examines how the T cell response interacts with the changing antigenic structure of viral antigens at the level of individual T cell clones.Escape from adaptive T-cell immunity through mutation of viral antigenic structure is a cardinal feature in the pathogenesis of SIV/HIV infection and a major obstacle to antiretroviral vaccine development. However, the molecular determinants of this phenomenon at the T-cell receptor (TCR)antigen interface are unknown. This study examines how the T cell response interacts with the changing antigenic structure of viral antigens at the level of individual T cell clones.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI005066-07
Application #
8148438
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2010
Total Cost
$815,584
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Schramm, Chaim A; Douek, Daniel C (2018) Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design. Front Immunol 9:1876
Buggert, Marcus; Nguyen, Son; Salgado-Montes de Oca, Gonzalo et al. (2018) Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue. Sci Immunol 3:
Wieland, Andreas; Kamphorst, Alice O; Adsay, N Volkan et al. (2018) T cell receptor sequencing of activated CD8 T cells in the blood identifies tumor-infiltrating clones that expand after PD-1 therapy and radiation in a melanoma patient. Cancer Immunol Immunother 67:1767-1776
Shugay, Mikhail; Bagaev, Dmitriy V; Zvyagin, Ivan V et al. (2018) VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Res 46:D419-D427
Ramesh, Akshaya; Darko, Sam; Hua, Axin et al. (2017) Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies. Front Immunol 8:1407
Breden, Felix; Luning Prak, Eline T; Peters, Bjoern et al. (2017) Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data. Front Immunol 8:1418
Afik, Shaked; Yates, Kathleen B; Bi, Kevin et al. (2017) Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state. Nucleic Acids Res 45:e148
Shmagel, K V; Saidakova, E V; Shmagel, N G et al. (2016) Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection. HIV Med 17:581-9
Lederman, Michael M; Cannon, Paula M; Currier, Judith S et al. (2016) A Cure for HIV Infection: ""Not in My Lifetime"" or ""Just Around the Corner""? Pathog Immun 1:154-164
Covacu, Ruxandra; Philip, Hagit; Jaronen, Merja et al. (2016) System-wide Analysis of the T Cell Response. Cell Rep 14:2733-44

Showing the most recent 10 out of 44 publications