We perform in depth analyses of the immune response to multiple different vaccines and to multiple different natural viral infections in order to dissect those immune responses that mediate protection from viral infection or dissemination. Antigen presenting cells are tracked from the time of vaccination to determine where and how they present antigen, and in what context, to B and T cells in the lymph nodes. The effects of chronic immune activation and antigen stimulation on the immune response to different pathogens are studied. In addition, the effects of HIV infection on different pathogen-specific T cell responses are evaluated.

Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2013
Total Cost
$1,263,878
Indirect Cost
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State
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Bhadra, Rajarshi; Moretto, Magali M; Castillo, Julio C et al. (2014) Intrinsic TGF-? signaling promotes age-dependent CD8+ T cell polyfunctionality attrition. J Clin Invest 124:2441-55
Riou, Catherine; Burgers, Wendy A; Mlisana, Koleka et al. (2014) Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point. J Virol 88:1819-24
Sambor, Anna; Garcia, Ambrosia; Berrong, Mark et al. (2014) Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials. J Immunol Methods 409:107-16
Johnson, Matthew J; Bjorkstrom, Niklas K; Petrovas, Constantinos et al. (2014) Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression. Vaccine 32:717-24
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Buggert, Marcus; Tauriainen, Johanna; Yamamoto, Takuya et al. (2014) T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection. PLoS Pathog 10:e1004251
Lubaki, Ndongala M; Ilinykh, Philipp; Pietzsch, Colette et al. (2013) The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains. J Virol 87:7471-85
Sandgren, Kerrie J; Smed-Sorensen, Anna; Forsell, Mattias N et al. (2013) Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation. J Immunol 191:60-9
Liang, Frank; Bond, Emily; Sandgren, Kerrie J et al. (2013) Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration. AIDS 27:1071-80
Petrovas, Constantinos; Yamamoto, Takuya; Price, David A et al. (2013) High Production Rates Sustain In Vivo Levels of PD-1high Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance. J Virol 87:9836-44

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