The isolation and characterization of Mesenchymal progenitor cells (MPCs) from traumatized human tissue obtained during wound debridements represents a valuable advance in our understanding of wound healing. These research samples have provided insight into the cells and the potential factors involved in tissue repair and regeneration and the development of heterotopic ossification. Understanding the role of MPCs in the tissue repair and regeneration process will improve our understanding of tissue genesis and the underlying mechanisms involved in both desirable and pathologic healing responses. Ultimately, we hope to be able to identify novel targets in the injury response that will lead to a more acceptable healing outcome.

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Project End
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Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$951,592
Indirect Cost
Name
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Department
Type
DUNS #
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Jackson, Wesley M; Alexander, Peter G; Bulken-Hoover, Jamie D et al. (2013) Mesenchymal progenitor cells derived from traumatized muscle enhance neurite growth. J Tissue Eng Regen Med 7:443-51
Jackson, Wesley M; Nesti, Leon J; Tuan, Rocky S (2012) Mesenchymal stem cell therapy for attenuation of scar formation during wound healing. Stem Cell Res Ther 3:20
Kluk, Matthew W; Ji, Youngmi; Shin, Emily H et al. (2012) Fibroregulation of mesenchymal progenitor cells by BMP-4 after traumatic muscle injury. J Orthop Trauma 26:693-8
Bulken-Hoover, Jamie D; Jackson, Wesley M; Ji, Youngmi et al. (2012) Inducible expression of neurotrophic factors by mesenchymal progenitor cells derived from traumatically injured human muscle. Mol Biotechnol 51:128-36
Nauth, Aaron; Giles, Erica; Potter, Benjamin K et al. (2012) Heterotopic ossification in orthopaedic trauma. J Orthop Trauma 26:684-8
Jackson, Wesley M; Nesti, Leon J; Tuan, Rocky S (2012) Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem Cells Transl Med 1:44-50
Christopherson, Gregory T; Nesti, Leon J (2011) Stem cell applications in military medicine. Stem Cell Res Ther 2:40
Jackson, Wesley M; Lozito, Thomas P; Djouad, Farida et al. (2011) Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. J Cell Mol Med 15:2377-88
Ji, Youngmi; Christopherson, Gregory T; Kluk, Matthew W et al. (2011) Heterotopic ossification following musculoskeletal trauma: modeling stem and progenitor cells in their microenvironment. Adv Exp Med Biol 720:39-50
Jackson, Wesley M; Aragon, Amber B; Onodera, Jun et al. (2011) Cytokine expression in muscle following traumatic injury. J Orthop Res 29:1613-20

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