The greater Baltimore area in Maryland has a large population of African-Americans and European-Americans, which makes this area most suitable to investigate differences in the exposure to prostate cancer risk factors among these two population groups. We designed a study that will use an integrated molecular epidemiology and translational research approach to examine causes for the excessive burden of prostate cancer among African-American men, including the study of tumor biological differences between African-American and European-American patients, supported by the collection of blood, urine, tissue samples, and survey data. Other epidemiological studies of prostate cancer have been established in recent years;however, only a few of these studies address the need for health disparity research and will have the opportunity to collect fresh-frozen tumor specimens from case subjects. Our study was implemented in two phases. The first phase, which started in April of 2005, constituted a pilot study to evaluate recruitment procedures. This phase was successful and the full study was initiated with minor changes to the protocol in April of 2006. Study participants will be African-American and European-American males who reside in Baltimore city and surrounding areas. The study will recruit 1000 prostate cancer cases and 1000 population-based controls, with recruitment ending in 2015. The cases are recruited at two Baltimore hospitals, the Veterans Affairs Medical Center and the University of Maryland Medical Center. Cases will have pathologically confirmed prostate cancer. The population-based controls are identified through the Maryland Department of Motor Vehicles database, and are frequency-matched by age and race to cases. The study involves the administration of two questionnaires and collection of blood and urine from all study subjects. Fresh-frozen tumor specimens will be obtained from cancer patients if available after prostatectomy. The study survey evaluates tobacco use, medication use, diet, medical and sexual history, familial cancer history, and socioeconomic status. The study is supported by an epidemiological infrastructure that has been developed by our resource contractor at the University of Maryland for a lung cancer case-control study. This lung cancer study is ongoing, and the controls that are recruited for the prostate cancer study are joint controls with the lung cancer study. Hence, population-based male controls recruited by our contractor have double eligibility for the concurrent lung and prostate cancer studies. To achieve an age and race matching of cases and controls in the prostate study, we will over-sample for male controls in the lung cancer study. This study and the ongoing lung study are described by a recently established website at (http://home.ccr.cancer.gov/GEMES/index.html). The website also describes the policy for collaborations involving data sharing. Study protocol and the two questionnaires can be accessed at: http://www3.cancer.gov/intra/lhc/Ambs/Prostate_Cancer_Case_Control_Study_Protocol.pdf http://www3.cancer.gov/intra/lhc/Ambs/Lung_Prostate_Case_Control_Questionnaire.pdf http://www3.cancer.gov/intra/lhc/Ambs/Prostate_Cancer_Supplementary Questionnaire.pdf Our study is aimed at identifying differences in risk factor exposure and tumor biology between African-American and European-American men. We will also test the hypothesis that environmental and genetic factors and their interactions contribute to the existing prostate cancer health disparity among African-Americans and European-Americans. Molecular work will be used to examine race/ethnic differences in tumor biology. Currently, we have enrolled 816 cases (429 European-Americans and 387 African-Americans) and 767 population-based controls (466 European-Americans and 301 African-Americans) and have collected blood and urine from these individuals. We have also collected paraffin-embedded and fresh-frozen tissue specimens form 127 prostatectomy surgeries. Future recruitment rates are set at 50-100 cases and 50-100 controls per year until the recruitment sealing of 500 African-American and 500 European-American cases and 500 African-American and 500 European-American controls is reached.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC010499-11
Application #
8763120
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2013
Total Cost
$583,310
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Karunasinghe, Nishi; Ambs, Stefan; Wang, Alice et al. (2018) Influence of lifestyle and genetic variants in the aldo-keto reductase 1C3 rs12529 polymorphism in high-risk prostate cancer detection variability assessed between US and New Zealand cohorts. PLoS One 13:e0199122
Tang, Wei; Wallace, Tiffany A; Yi, Ming et al. (2018) IFNL4-?G Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer. Clin Cancer Res 24:5471-5481
Smith, Cheryl J; Minas, Tsion Z; Ambs, Stefan (2018) Analysis of Tumor Biology to Advance Cancer Health Disparity Research. Am J Pathol 188:304-316
Pichardo, Margaret S; Smith, Cheryl J; Dorsey, Tiffany H et al. (2018) Association of Anthropometric Measures with Prostate Cancer among African American Men in the NCI-Maryland Prostate Cancer Case-Control Study. Cancer Epidemiol Biomarkers Prev 27:936-944
Minas, Tsion Zewdu; Tang, Wei; Smith, Cheryl J et al. (2018) IFNL4-?G is associated with prostate cancer among men at increased risk of sexually transmitted infections. Commun Biol 1:191
Smith, Cheryl Jacobs; Dorsey, Tiffany H; Tang, Wei et al. (2017) Aspirin Use Reduces the Risk of Aggressive Prostate Cancer and Disease Recurrence in African-American Men. Cancer Epidemiol Biomarkers Prev 26:845-853
Prueitt, Robyn L; Wallace, Tiffany A; Glynn, Sharon A et al. (2016) An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers. Cancer Res 76:1055-1065
Mishra, Prachi; Ambs, Stefan (2015) Metabolic Signatures of Human Breast Cancer. Mol Cell Oncol 2:
Downey, Ronan F; Sullivan, Francis J; Wang-Johanning, Feng et al. (2015) Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice? Int J Cancer 137:1249-57
Wallace, Tiffany A; Downey, Ronan F; Seufert, Caleb J et al. (2014) Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers. Carcinogenesis 35:2074-83

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