We have transitioned from evaluating the skin bacterial microbiome of multiple skin sites in healthy adults to investigating the relevance of the skin microbiome fluctuations to skin diseases. In fiscal year 2012, we completed analysis and published a manuscript about the skin microbiome in patients with atopic dermatitis (eczema). We continue to study the skin microbiome in patients primary immunodeficiencies with dermatitis (hyper-IgE syndrome and Wiskott-Aldrich syndrome), in addition to follow-up sampling visits from previously enrolled subjects. The sequencing for this project is funded by the National Institutes of Health Roadmap Project, The Human Microbiome Project. We have been analyzing the microbiome data from patients with atopic dermatitis, hyper-IgE syndrome and Wiskott-Aldrich syndrome in the last fiscal year. We have also been studying the fungal microbiome in healthy adults.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC010938-05
Application #
8552891
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2012
Total Cost
$857,285
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Jo, Jay-Hyun; Kennedy, Elizabeth A; Kong, Heidi H (2016) Research Techniques Made Simple: Bacterial 16S Ribosomal RNA Gene Sequencing in Cutaneous Research. J Invest Dermatol 136:e23-7
Tsai, Yu-Chih; Conlan, Sean; Deming, Clayton et al. (2016) Resolving the Complexity of Human Skin Metagenomes Using Single-Molecule Sequencing. MBio 7:e01948-15
Kong, Heidi H (2016) Details Matter: Designing Skin Microbiome Studies. J Invest Dermatol 136:900-2
Oh, Julia; Byrd, Allyson L; Park, Morgan et al. (2016) Temporal Stability of the Human Skin Microbiome. Cell 165:854-66
Naik, Shruti; Bouladoux, Nicolas; Linehan, Jonathan L et al. (2015) Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Nature 520:104-8
Waldor, Matthew K; Tyson, Gene; Borenstein, Elhanan et al. (2015) Where next for microbiome research? PLoS Biol 13:e1002050
Cuellar-Rodriguez, Jennifer; Freeman, Alexandra F; Grossman, Jennifer et al. (2015) Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK8 deficiency. Biol Blood Marrow Transplant 21:1037-45
Kobayashi, Tetsuro; Glatz, Martin; Horiuchi, Keisuke et al. (2015) Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis. Immunity 42:756-66
Oh, Julia; Byrd, Allyson L; Deming, Clay et al. (2014) Biogeography and individuality shape function in the human skin metagenome. Nature 514:59-64
Oh, Julia; Freeman, Alexandra F; NISC Comparative Sequencing Program et al. (2013) The altered landscape of the human skin microbiome in patients with primary immunodeficiencies. Genome Res 23:2103-14

Showing the most recent 10 out of 23 publications