We have expanded our work by including studies of fungi as part of the human skin microbiome of multiple skin sites in healthy adults as well as continued to investigate the relevance of the skin microbiome fluctuations to skin diseases. In fiscal year 2013, we completed analysis and published a manuscript about the fungal skin microbiome healthy adults. We continue to study the skin microbiome in patients primary immunodeficiencies with dermatitis (hyper-IgE syndrome and Wiskott-Aldrich syndrome), in addition to follow-up sampling visits from previously enrolled subjects. The sequencing for this project is funded by the National Institutes of Health Roadmap Project, The Human Microbiome Project. We have been continuing to analyze the microbiome data from patients with atopic dermatitis, hyper-IgE syndrome and Wiskott-Aldrich syndrome in the last fiscal year.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC010938-06
Application #
8763273
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$550,573
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Oh, Julia; Byrd, Allyson L; Deming, Clay et al. (2014) Biogeography and individuality shape function in the human skin metagenome. Nature 514:59-64
Grice, Elizabeth A; Kong, Heidi H; Conlan, Sean et al. (2009) Topographical and temporal diversity of the human skin microbiome. Science 324:1190-2
Grice, Elizabeth A; Kong, Heidi H; Renaud, Gabriel et al. (2008) A diversity profile of the human skin microbiota. Genome Res 18:1043-50