We used a novel methode to identify asymmetric division in keeping with the immortal strand hyp[othesis. We subsequently, identified a novel factor: the self-renewal factor that induces asymmetric division in cancer stem cells. We plan to purify this protein and generate novwl anticancer therapy by blocking its receptor or the facore itself inorder to stop self renewal. In addition by identifying the asymmetrically dividing cells in cancer (for the first time) we subsequently identified markers which are associated specifically with cancer stem cells.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011003-03
Application #
8157572
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2010
Total Cost
$260,183
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Ray, Satyajit; Langan, Russell C; Mullinax, John E et al. (2012) Establishment of human ultra-low passage colorectal cancer cell lines using spheroids from fresh surgical specimens suitable for in vitro and in vivo studies. J Cancer 3:196-206
Mullinax, John E; Allins, Alexander; Avital, Itzhak (2011) Laparoscopic appendectomy for Amyand's hernia: a modern approach to a historic diagnosis. J Gastrointest Surg 15:533-5
Avital, Itzhak (2011) Regional chemotherapy for pancreatic cancer. J Surg Oncol 104:453