We used a novel methode to identify asymmetric division in keeping with the immortal strand hyp[othesis. We subsequently, identified a novel factor: the self-renewal factor that induces asymmetric division in cancer stem cells. We plan to purify this protein and generate novwl anticancer therapy by blocking its receptor or the facore itself inorder to stop self renewal. In addition by identifying the asymmetrically dividing cells in cancer (for the first time) we subsequently identified markers which are associated specifically with cancer stem cells.
|Ray, Satyajit; Langan, Russell C; Mullinax, John E et al. (2012) Establishment of human ultra-low passage colorectal cancer cell lines using spheroids from fresh surgical specimens suitable for in vitro and in vivo studies. J Cancer 3:196-206|
|Mullinax, John E; Allins, Alexander; Avital, Itzhak (2011) Laparoscopic appendectomy for Amyand's hernia: a modern approach to a historic diagnosis. J Gastrointest Surg 15:533-5|
|Avital, Itzhak (2011) Regional chemotherapy for pancreatic cancer. J Surg Oncol 104:453|