Abstract

As a new lab starting in 2009, we have been able to hire talented postdoc and graduate students working on this project. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in tumor cells or host immature myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We are currently investigating mechanisms which involves systemic immune response as well as tumor microenvironment. We are utilizing technical core resources and collaborating with several labs for this project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011163-02
Application #
8157666
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2010
Total Cost
$606,693
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Yan, Hangyi H; Jiang, Jian; Pang, Yanli et al. (2015) CCL9 Induced by TGF? Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ. Cancer Res 75:5283-98
Luger, Dror; Yang, Yu-An; Raviv, Asaf et al. (2013) Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. PLoS One 8:e76115
Pang, Yanli; Gara, Sudheer Kumar; Achyut, Bhagelu R et al. (2013) TGF-? signaling in myeloid cells is required for tumor metastasis. Cancer Discov 3:936-51
Yang, Li; Edwards, Claire M; Mundy, Gregory R (2010) Gr-1+CD11b+ myeloid-derived suppressor cells: formidable partners in tumor metastasis. J Bone Miner Res 25:1701-6
Yang, L (2010) TGFbeta, a potent regulator of tumor microenvironment and host immune response, implication for therapy. Curr Mol Med 10:374-80
Hembruff, Stacey L; Jokar, Iman; Yang, Li et al. (2010) Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophage-dependent and -independent mechanisms. Neoplasia 12:425-33
Yang, Li (2010) TGFbeta and cancer metastasis: an inflammation link. Cancer Metastasis Rev 29:263-71
Yang, Li; Pang, Yanli; Moses, Harold L (2010) TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol 31:220-7