Abstract

We have started this project and isolated RNA from 25 pairs of snap-frozen pancreatic ductal adenocarcinoma (PDAC) samples and the surrounding non-tumorous pancreas from the same patients and 3 normal pancreas from non-cancer donors that have been collected through the NCI-University of Maryland Resource Contract. These RNA samples are being analyzed to determine the expression of a set of 25 inflammatory genes with real-time polymerase chain reaction technique. Paraffin sections of the same sample set are being examined for the expression of NOS2, phospho-FoxO, MIF and phospho-Akt by immunohistochemical staining.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011185-01
Application #
7966177
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2009
Total Cost
$217,618
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Wang, Jian; Hussain, S Perwez (2017) NO(•) and Pancreatic Cancer: A Complex Interaction with Therapeutic Potential. Antioxid Redox Signal 26:1000-1008
Wang, Jian; He, Peijun; Gaida, Matthias et al. (2016) Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer. Oncotarget :
Yang, Shouhui; He, Peijun; Wang, Jian et al. (2016) A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2. Cancer Res 76:3838-50
Hussain, S Perwez (2016) Pancreatic Cancer: Current Progress and Future Challenges. Int J Biol Sci 12:270-2
Alam, Muhammad S; Gaida, Matthias M; Bergmann, Frank et al. (2015) Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. Nat Med 21:1337-43
Funamizu, Naotake; Hu, Chaoxin; Lacy, Curtis et al. (2013) Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma. Int J Cancer 132:785-94