There are several sections of this project involving different aspects of imaging. 1. MR sequences: We are currently working in the Laboratory of Diagnostic Radiology Research evaluating multiple MR sequences on children with brain tumors, longitudinally, to assess outcome to tehrapy and prognostic factors. These imaging modalities include spectroscopy (single voxel, CSI and multislice multivoxel), perfusion studies (DEMRI, DSC-MRI) and diffusion tenor imaging. 2. Results from NMRS are being compared to the "gold standard" in adult neuro-oncology, i.e. FDG-PET, to determine the correlation between results of each modality.
|Chittiboina, Prashant; Heiss, John D; Warren, Katherine E et al. (2014) Magnetic resonance imaging properties of convective delivery in diffuse intrinsic pontine gliomas. J Neurosurg Pediatr 13:276-82|
|Steffen-Smith, Emilie A; Baker, Eva H; Venzon, David et al. (2014) Measurements of the pons as a biomarker of progression for pediatric DIPG. J Neurooncol 116:127-33|
|Warren, Katherine E; Poussaint, Tina Y; Vezina, Gilbert et al. (2013) Challenges with defining response to antitumor agents in pediatric neuro-oncology: a report from the response assessment in pediatric neuro-oncology (RAPNO) working group. Pediatr Blood Cancer 60:1397-401|