Abstract

We will be collaborating with centers which are generating genetic expression data on both human tumors and normal tissues to seek candidate proteins suitable for immune attack. Thusfar, we have succeeded in generating and optimizing a chimeric antigen receptor targeting CD70, a protein on nearly all human renal cancer and many blood cancers is also in the final stages of development. In addition, a mouse T-cell receptor that functions well in human T-cells and recognizes human thyroglobulin as a thyroid cancer antigen has been cloned and a clinical procotol for differentiated thyroid cancer is now open to accrual. Currently we are developing T-cell receptor that immunologically recognize consistently mutated driver mutations common in certain human cancers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011337-06
Application #
9153871
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Yang, James C (2017) Debugging the Black Box. Cancer Discov 7:250-251
Jin, Linchun; Ge, Haitao; Long, Yu et al. (2017) CD70, a novel target of CAR-T-cell therapy for gliomas. Neuro Oncol :
Klemen, Nicholas D; Feingold, Paul L; Goff, Stephanie L et al. (2017) Metastasectomy Following Immunotherapy with Adoptive Cell Transfer for Patients with Advanced Melanoma. Ann Surg Oncol 24:135-141
Wang, Qiong J; Yu, Zhiya; Hanada, Ken-Ichi et al. (2017) Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers. Clin Cancer Res 23:2267-2276
Yang, James C (2016) The Immunotherapy Roadmap. Clin Cancer Res 22:275-6
Yang, James C; Rosenberg, Steven A (2016) Adoptive T-Cell Therapy for Cancer. Adv Immunol 130:279-94
Gros, Alena; Parkhurst, Maria R; Tran, Eric et al. (2016) Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Nat Med 22:433-8
Gros, Alena; Robbins, Paul F; Yao, Xin et al. (2014) PD-1 identifies the patient-specific CD8? tumor-reactive repertoire infiltrating human tumors. J Clin Invest 124:2246-59
Tran, Eric; Turcotte, Simon; Gros, Alena et al. (2014) Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344:641-5
Lu, Yong-Chen; Yao, Xin; Li, Yong F et al. (2013) Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression. J Immunol 190:6034-42

Showing the most recent 10 out of 11 publications