As an effort to obtain specimens that might be useful in the study of the presence on specific antigens in tumor types, anonymous tissue donations were accepted. We described a method to generate multitumor blocks without specific equipment. With these tissues, we characterized the distribution of several endothelial antigens: Claudin 5, PROX1, and VEGFR2 (KDR gene product). Also distribution of KBA62 and PNL 2 antigens in melanoma and other tumors was examined. We found VEGFR2 highly specific for endothelial tumors among mesenchymal cancers, but malignant mesotheliomas were found to be unique epithelial cancers strongly positive for VEGFR2. We also examined succinate dehydrogenase deficient gastrointestinal stromal tumors, in collaboration with NCI's pediatric GIST clinic.

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National Cancer Institute (NCI)
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National Cancer Institute Division of Basic Sciences
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Inaguma, Shingo; Wang, Zengfeng; Lasota, Jerzy P et al. (2016) Expression of neural cell adhesion molecule L1 (CD171) in neuroectodermal and other tumors. An immunohistochemical study of 5155 tumors and critical evaluation of CD171 prognostic value in gastrointestinal stromal tumors. Oncotarget :
Inaguma, Shingo; Wang, Zengfeng; Lasota, Jerzy et al. (2016) Comprehensive Immunohistochemical Study of Programmed Cell Death Ligand 1 (PD-L1): Analysis in 5536 Cases Revealed Consistent Expression in Trophoblastic Tumors. Am J Surg Pathol 40:1133-42
Kerkar, Sid P; Wang, Zeng-Feng; Lasota, Jerzy et al. (2016) MAGE-A is More Highly Expressed Than NY-ESO-1 in a Systematic Immunohistochemical Analysis of 3668 Cases. J Immunother 39:181-7
Thompson, Lester D R; Bauer, Justin L; Chiosea, Simion et al. (2015) Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature. Head Neck Pathol 9:181-95
Miettinen, Markku; Wang, Zengfeng; Lasota, Jerzy et al. (2015) Nuclear Brachyury Expression Is Consistent in Chordoma, Common in Germ Cell Tumors and Small Cell Carcinomas, and Rare in Other Carcinomas and Sarcomas: An Immunohistochemical Study of 5229 Cases. Am J Surg Pathol 39:1305-12
Lasota, Jerzy; Felisiak-Golabek, Anna; Aly, F Zahra et al. (2015) Nuclear expression and gain-of-function β-catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker. Mod Pathol 28:715-20
Miettinen, Markku; McCue, Peter A; Sarlomo-Rikala, Maarit et al. (2015) Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol 39:826-35
Miettinen, Markku (2014) Immunohistochemistry of soft tissue tumours - review with emphasis on 10 markers. Histopathology 64:101-18
Miettinen, Markku; McCue, Peter A; Sarlomo-Rikala, Maarit et al. (2014) GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. Am J Surg Pathol 38:13-22
Killian, J Keith; Kim, Su Young; Miettinen, Markku et al. (2013) Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. Cancer Discov 3:648-57

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