In an effort to identify small molecules with anti-Alzheimer's potential, we recently carried out a screen for molecules that disrupt the binding of abeta to receptor-expressing cells. A hit molecule from this screen was revealed to be an oligomeric degradation product of a known molecule. The specific structure of this oligomeric degradation product has been elusive: it appears to be polydispersed and may not be a single structure. However, extensive biochemical and animal studies revealed that it has significant potential as a therapeutic. Our efforts to date have revolved around generating synthetic material that mimics the behavior of the degradation product, and studying structure-activity relationships of this fascinating molecule. In collaboration with Stephen Strittmatter (Yale University) we have used a variety of analytical and synthetic techniques to further characterize the compound

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011452-01
Application #
8553197
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2012
Total Cost
$126,319
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
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State
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