Abstract

We utilized high throughput screening technologies to help identify compounds and extracts that can specifically interact with or modulate the function of selected biochemical targets or processes. Bioassay-guided chemical fractionation of natural products extracts is employed to isolate and purify the individual bioactive compounds. Identification and structural characterization of these compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes that can interact with the desired molecular target. In addition to extensive NMR and mass spectroscopic analyses, our efforts include rigorous evaluation of a new compound's potency, molecular target specificity, and mode of action.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011568-01
Application #
8938200
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Tian, Xiang Rong; Tang, Hai Feng; Tian, Xiao Lin et al. (2018) Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery. Future Med Chem 10:1497-1514
Liu, Yizhou; Cohen, Ryan D; Gustafson, Kirk R et al. (2018) Enhanced measurement of residual chemical shift anisotropy for small molecule structure elucidation. Chem Commun (Camb) 54:4254-4257
Milanowski, Dennis J; Oku, Naoya; Cartner, Laura K et al. (2018) Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box. Chem Sci 9:307-314
Irie, Raku; Takada, Kentaro; Ise, Yuji et al. (2017) Structure Revision of Poecillastrin C and the Absolute Configuration of the ?-Hydroxyaspartic Acid Residue. Org Lett 19:5395-5397
Yuan, Weiping; Cheng, Shimiao; Fu, Weitao et al. (2016) Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea. J Nat Prod 79:1124-31
Zhao, Min; Cheng, Shimiao; Yuan, Weiping et al. (2016) Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum. Mar Drugs 14:
Goey, Andrew K L; Chau, Cindy H; Sissung, Tristan M et al. (2016) Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1?/p300 Interaction. J Nat Prod 79:1267-75
Shin, Hee Jae; Rashid, Mohammad A; Cartner, Laura K et al. (2015) Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp. Tetrahedron Lett 56:4215-4219
Henrich, Curtis J; Cartner, Laura K; Wilson, Jennifer A et al. (2015) Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts. J Nat Prod 78:2776-81
Henrich, C J; Brooks, A D; Erickson, K L et al. (2015) Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell Death Dis 6:e1666

Showing the most recent 10 out of 16 publications