Modulation of Radiation Response

Kesarwala, Aparna

Abstract

We have tested several novel modulators that target the pathways relevant to ionizing radiation. We have used clonogenic survival assays of human tumor cells in vitro to characterize the temporal components and dose-dependency of the response to ionizing radiation. We have also begun testing these modulators in in vivo xenograft models to determine the correlation with our in vitro results. We have also begun investigating potential mechanisms and related pathways in order to better understand our results.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIABC011575-01
• Application #: 8938201
• Support Year: 1
• Fiscal Year: 2014

Institution

• Name: Basic Sciences

Publications

Kambach, Diane M; Halim, Alan S; Cauer, A Gesine et al. (2017) Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma. Oncotarget 8:14860-14875

Kesarwala, A H; Krishna, M C; Mitchell, J B (2016) Oxidative stress in oral diseases. Oral Dis 22:9-18

Ma, Chi; Kesarwala, Aparna H; Eggert, Tobias et al. (2016) NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature 531:253-7

Ridnour, Lisa A; Cheng, Robert Y S; Weiss, Jonathan M et al. (2015) NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay. Cancer Res 75:2788-99

Kesarwala, Aparna H; Ko, Christine J; Ning, Holly et al. (2015) Intensity-modulated proton therapy for elective nodal irradiation and involved-field radiation in the definitive treatment of locally advanced non-small-cell lung cancer: a dosimetric study. Clin Lung Cancer 16:237-44

Cheng, Robert Y S; Basudhar, Debashree; Ridnour, Lisa A et al. (2014) Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways. Nitric Oxide 43:17-28