We have submitted and have had accepted our proposal for synthesis of a novel imaging probe through the Imaging Probe Development Center (IPDC), which is part of the NHLBI. We have spent time calibrating and optimizing procedures and imaging equipment as well as developing relevant in vivo/animal systems along with in vitro systems for correlative studies. This is a highly collaborative project being pursued with Drs. Murali K. Cherukuri and James B. Mitchell of the Radiation Biology Branch, NCI.
|Takakusagi, Yoichi; Matsumoto, Shingo; Saito, Keita et al. (2014) Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302. PLoS One 9:e107995|