Major etiologic investigations focus on working populations exposed to benzene, trichloroethylene, other organic solvents, formaldehyde, diesel exhausts, combustion products, electromagnetic fields, pesticides, and silica. Findings linking cancer with occupational exposures included an excess of nasopharyngeal cancer and leukemia among workers exposed to formaldehyde;breast cancer among women in Shanghai was associated with employment in the textile industry, medical profession, and the telecommunications industry. A cohort of U.S. Coast Guard shipyard workers was found to have elevated mortality from emphysema, lung cancer, and mesothelioma, while a cohort of Coast Guard marine inspectors, who carry out ship inspections involving exposure to a variety of chemicals, showed excess deaths from cirrhosis of the liver and chronic rheumatic heart disease. Among other industrial studies, a cohort of workers engaged in the repair and maintenance of aircraft and missiles showed no clear exposure-response gradient for TCE with any cancer, but did show an approximately two-fold excess of renal disease. We have also reported findings from a variety of case-control studies that have examined occupation and cancer risks, including bladder cancer in Spain, kidney cancer in Europe, lung cancer in Russia and Turkey, pancreas cancer in Iowa, and breast cancer in Poland. Other studies are evaluating brain cancer risk from electromagnetic fields (EMF), relying on quantitative exposure estimates from job-specific modules. Methodologic studies dealt with confounding and exposure misclassification, quantitative exposure assessment, and exposures and urinary mutagenicity in rubber workers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010120-14
Application #
7966593
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2009
Total Cost
$2,460,178
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Dai, Yufei; Ren, Dianzhi; Bassig, Bryan A et al. (2018) Occupational exposure to diesel engine exhaust and serum cytokine levels. Environ Mol Mutagen 59:144-150
Silverman, Debra T (2018) Diesel Exhaust and Lung Cancer-Aftermath of Becoming an IARC Group 1 Carcinogen. Am J Epidemiol 187:1149-1152
Lerro, Catherine C; Jones, Rena R; Langseth, Hilde et al. (2018) A nested case-control study of polychlorinated biphenyls, organochlorine pesticides, and thyroid cancer in the Janus Serum Bank cohort. Environ Res 165:125-132
Wong, Jason Y Y; Bassig, Bryan A; Seow, Wei Jie et al. (2017) Lung cancer risk in welders and foundry workers with a history of heavy smoking in the USA: The National Lung Screening Trial. Occup Environ Med 74:440-448
Silverman, Debra T (2017) Diesel exhaust causes lung cancer: now what? Occup Environ Med 74:233-234
Bassig, Bryan A; Dai, Yufei; Vermeulen, Roel et al. (2017) Occupational exposure to diesel engine exhaust and alterations in immune/inflammatory markers: a cross-sectional molecular epidemiology study in China. Carcinogenesis 38:1104-1111
Silverman, Debra T; Attfield, Michael D; Blair, Aaron E et al. (2016) Re: ""The hidden impact of a healthy-worker effect on the results of the Diesel Exhaust in Miners Study"". Eur J Epidemiol 31:805-6
Dai, Yufei; Niu, Yong; Duan, Huawei et al. (2016) Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets. Environ Mol Mutagen 57:615-622
Portengen, L├╝tzen; Linet, Martha S; Li, Gui-Lan et al. (2016) Retrospective benzene exposure assessment for a multi-center case-cohort study of benzene-exposed workers in China. J Expo Sci Environ Epidemiol 26:334-40
Linet, Martha S; Yin, Song-Nian; Gilbert, Ethel S et al. (2015) A retrospective cohort study of cause-specific mortality and incidence of hematopoietic malignancies in Chinese benzene-exposed workers. Int J Cancer 137:2184-97

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