Ongoing and planned studies include evaluation of populations exposed to benzene, chlorinated solvents, organochlorines, disinfection byproducts. polycyclic aromatic hydrocarbons, arsenic, formaldehyde, diesel exhaust, coal combustion products, and selected pesticides. On-going case-control studies of stomach, esophagus, brain, bladder, renal cell, thyroid, prostate and breast cancer, NHL, and benzene-induced hematotoxicity and hematologic malignancies and cohort studies of women in China and agricultural workers in the United States are evaluating a range of potential genetic risk factors and their interaction with occupational and environmental exposures. Many of these studies are also collecting tumor samples for future molecular analyses.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
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Division of Cancer Epidemiology and Genetics
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Thomas, Reuben; Hubbard, Alan E; McHale, Cliona M et al. (2014) Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure. PLoS One 9:e91828
Kim, Christopher; Chapman, Robert S; Hu, Wei et al. (2014) Smoky coal, tobacco smoking, and lung cancer risk in Xuanwei, China. Lung Cancer 84:31-5
Bassig, Bryan A; Zhang, Luoping; Cawthon, Richard M et al. (2014) Alterations in leukocyte telomere length in workers occupationally exposed to benzene. Environ Mol Mutagen 55:673-8
Zhang, Luoping; Bassig, Bryan A; Mora, Joseph L et al. (2013) Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene. Carcinogenesis 34:799-802
Bassig, Bryan A; Zhang, Luoping; Tang, Xiaojiang et al. (2013) Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha. Environ Mol Mutagen 54:450-4
Robles, Claudia; Viscidi, Raphael; Malats, Nuria et al. (2013) Bladder cancer and seroreactivity to BK, JC and Merkel cell polyomaviruses: the Spanish bladder cancer study. Int J Cancer 133:597-603
Lan, Qing; Zhang, Luoping; Shen, Min et al. (2009) Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis 30:50-8
Lan, Qing; He, Xingzhou; Shen, Min et al. (2008) Variation in lung cancer risk by smoky coal subtype in Xuanwei, China. Int J Cancer 123:2164-9
Lan, Qing; Lim, Unhee; Liu, Chin-San et al. (2008) A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma. Blood 112:4247-9