Ongoing and planned studies include evaluation of populations exposed to benzene, chlorinated solvents, organochlorines, disinfection byproducts. polycyclic aromatic hydrocarbons, arsenic, formaldehyde, diesel exhaust, coal combustion products, and selected pesticides. On-going case-control studies of stomach, esophagus, brain, bladder, renal cell, thyroid, prostate and breast cancer, NHL, and benzene-induced hematotoxicity and hematologic malignancies and cohort studies of women in China and agricultural workers in the United States are evaluating a range of potential genetic risk factors and their interaction with occupational and environmental exposures. Many of these studies are also collecting tumor samples for future molecular analyses.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010121-19
Application #
8938224
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Wong, Jason Y Y; Margolis, Helene G; Machiela, Mitchell et al. (2018) Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study. Environ Int 116:239-247
Grigoryan, Hasmik; Edmands, William M B; Lan, Qing et al. (2018) Adductomic signatures of benzene exposure provide insights into cancer induction. Carcinogenesis 39:661-668
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Seow, Wei Jie; Lan, Qing (2016) Domestic incense use and lung cancer in Asia: a review. Rev Environ Health 31:155-8

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