The following reserach projects are etiologic and human population based and all have various molecular components: SUCCEED directed by Dr. Wentzensen is a cross-sectional study among women referred for abnormal cevrical cancer screening results focused on the identification of biomarkers of risk at each progressive disease stage, aimed to identify the molecular events that are necessary and sufficient for progression to cervical cancer. Frozen specimens, often multiple, from 2,500 women with varying grades of cervical neoplasia (including the ectocervix, transformation zone, and endocervix) have already been collected. In a new study, the Biopsy Study conducted at the same center in Oklahoma, Dr. Wentzensen is investigating the earliest discernible transitions from HPV infection to CIN3 and the best methods for colposcopic detection of CIN3 to improve current cervical cancer prevention strategies. The ALTS clinical trial evaluated management options for women with abnormal cervical cancer screening results and has been completed several years ago. The specimens collected in women with minor cytological abnormalities and 2 year follow up still serve as an important resource to evaluate HPV tests and novel biomarkers, such as viral methylation. The Anal Cancer Screening Study in HIV positive men who have sex with men is conducted with Kaiser Permanente Northern California to identify the HPV genotype attribution in anal precancer and to study biomarkers for anal cancer screening The Intramural to India project is a new effort to study cervical cancer precursors among HIV-infected women in India. In the Triage of HPV-positive women Study, novel biomarkers are evaluated to decide who among HPV+/cytology- women needs referral to colposcopy. The cervical tissue immune markers study aims at evaluating various components of the cellular and humoral immune system across cervical disease stages in HIV-infected populations. The case control study of invasive cervical cancer in four Latin-American countries is an important resource to study sero-epidemiologic markers of cervical cancer risk.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010124-17
Application #
8565419
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2012
Total Cost
$885,682
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Clarke, Megan A; Luhn, Patricia; Gage, Julia C et al. (2017) Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer. Int J Cancer 141:701-710
Schiffman, Mark (2017) Cervical cancer screening: Epidemiology as the necessary but not sufficient basis of public health practice. Prev Med 98:3-4
Wentzensen, Nicolas; Arbyn, Marc (2017) HPV-based cervical cancer screening- facts, fiction, and misperceptions. Prev Med 98:33-35
Schiffman, Mark; Wentzensen, Nicolas; Khan, Michelle J et al. (2017) Preparing for the Next Round of ASCCP-Sponsored Cervical Screening and Management Guidelines. J Low Genit Tract Dis 21:87-90
Schiffman, Mark; Yu, Kai; Zuna, Rosemary et al. (2017) Proof-of-principle study of a novel cervical screening and triage strategy: Computer-analyzed cytology to decide which HPV-positive women are likely to have ?CIN2. Int J Cancer 140:718-725
Wentzensen, Nicolas; Arbyn, Marc; Berkhof, Johannes et al. (2017) Eurogin 2016 Roadmap: how HPV knowledge is changing screening practice. Int J Cancer 140:2192-2200
Wentzensen, N (2017) Optimising cervical cancer screening programs: how to evaluate incremental changes? BJOG 124:485
Wentzensen, N; Litwin, T (2017) Accuracy of visual cervical screening: verification bias revisited. BJOG :
Wentzensen, Nicolas; Silver, Michelle I (2016) Biomarkers for Cervical Cancer Prevention Programs: The Long and Winding Road From Discovery to Clinical Use. J Low Genit Tract Dis 20:191-4
Bodelon, Clara; Vinokurova, Svetlana; Sampson, Joshua N et al. (2016) Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis 37:188-196

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