Studies of diet and obesity with liver cancer: Liver cancer is the third leading cause of cancer-related mortality worldwide. Numerous hypotheses link different aspects of the diet, e.g. alcohol, meat, fat, fruits and vegetables, coffee, fruit juice, with liver cancer. However of that list, only alcohol is an established risk factor. In addition to dietary components, there is a growing awareness of the importance of energy balance, including obesity, diabetes, and physical activity with liver cancer. We are investigating these dietary and energy balance hypotheses, taking advantage of large prospective cohort studies. In the past year, we have measured Hepatitis B (HBV) and Hepatitis C (HCV) positivity in several of our studies. HBV and HCV are strong risk factors for liver cancer and so now we can take account of these possible risk factors in our analyses. We have also measured several other analytes including insulin, glucose, vitamin D, and serum iron and aim to determine the association of these analytes with cancer. We are also in the process of examining associations with specific dietary components. SEER-Medicare. We have worked to create a nested-case control study in the SEER-Medicare database in which to examine the association of diet and obesity related exposures with cancer risk. The very large size of the SEER-Medicare database allows us to examine hypotheses which are difficult to conduct other places-- for example the association of diabetes with particular anatomic sub-sites of the colon. This year, we have developed the database and examined an initial set of exposures including obesity, diabetes, smoking, and gastric reflux.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010127-16
Application #
8351078
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
2011
Total Cost
$410,870
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Lai, Gabriel Y; Wang, Jian-Bing; Weinstein, Stephanie J et al. (2018) Association of 25-Hydroxyvitamin D with Liver Cancer Incidence and Chronic Liver Disease Mortality in Finnish Male Smokers of the ATBC Study. Cancer Epidemiol Biomarkers Prev 27:1075-1082
Loftfield, Erikka; O'Brien, Thomas R; Pfeiffer, Ruth M et al. (2016) Vitamin D Status and Virologic Response to HCV Therapy in the HALT-C and VIRAHEP-C Trials. PLoS One 11:e0166036
Sinha, Rashmi; Vogtmann, Emily; Chen, Jun et al. (2016) Fecal Microbiome in Epidemiologic Studies-Response. Cancer Epidemiol Biomarkers Prev 25:870-1
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Loftfield, Erikka; Freedman, Neal D; Lai, Gabriel Y et al. (2016) Higher Glucose and Insulin Levels Are Associated with Risk of Liver Cancer and Chronic Liver Disease Mortality among Men without a History of Diabetes. Cancer Prev Res (Phila) 9:866-874
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Freedman, Neal D; Marrero, Jorge A (2012) Can dietary fish intake prevent liver cancer? Gastroenterology 142:1411-3
Sinha, Rashmi; Daniel, Carrie R; Devasenapathy, Niveditha et al. (2011) Multi-center feasibility study evaluating recruitment, variability in risk factors and biomarkers for a diet and cancer cohort in India. BMC Public Health 11:405

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