Studies of diet and obesity with liver cancer: Liver cancer is the third leading cause of cancer-related mortality worldwide. Numerous hypotheses link different aspects of the diet, e.g. alcohol, meat, fat, fruits and vegetables, coffee, fruit juice, with liver cancer. However of that list, only alcohol is an established risk factor. In addition to dietary components, there is a growing awareness of the importance of energy balance, including obesity, diabetes, and physical activity with liver cancer. We are investigating these dietary and energy balance hypotheses, taking advantage of large prospective cohort studies. In the past couple of years, we have measured Hepatitis B (HBV) and Hepatitis C (HCV) positivity in several of our studies. HBV and HCV are strong risk factors for liver cancer and so now we can take account of these possible risk factors in our analyses. We have also measured several other analytes including insulin, glucose, vitamin D, and serum iron and aim to determine the association of these analytes with cancer. We are also in the process of examining associations with specific dietary components, such as meat, fat, coffee, and fruits and vegetables. Finally, we are examining lifestyle factors such as smoking and NSAID use. SEER-Medicare. We have worked to create a nested-case control study in the SEER-Medicare database in which to examine the association of diet and obesity related exposures with cancer risk. The very large size of the SEER-Medicare database allows us to examine hypotheses which are difficult to conduct other places-- for example the association of diabetes with particular anatomic sub-sites of the colon. We have developed the database and examined an initial set of exposures including obesity, diabetes, smoking, ulcers, gastric reflux, and pernicious anemia.

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National Cancer Institute (NCI)
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Loftfield, Erikka; O'Brien, Thomas R; Pfeiffer, Ruth M et al. (2016) Vitamin D Status and Virologic Response to HCV Therapy in the HALT-C and VIRAHEP-C Trials. PLoS One 11:e0166036
Sinha, Rashmi; Vogtmann, Emily; Chen, Jun et al. (2016) Fecal Microbiome in Epidemiologic Studies-Response. Cancer Epidemiol Biomarkers Prev 25:870-1
Loftfield, Erikka; Freedman, Neal D (2016) Higher coffee consumption is associated with lower risk of all-cause and cause-specific mortality in three large prospective cohorts. Evid Based Med 21:108
Loftfield, Erikka; Freedman, Neal D; Lai, Gabriel Y et al. (2016) Higher Glucose and Insulin Levels Are Associated with Risk of Liver Cancer and Chronic Liver Disease Mortality among Men without a History of Diabetes. Cancer Prev Res (Phila) 9:866-874
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Sinha, Rashmi; Daniel, Carrie R; Devasenapathy, Niveditha et al. (2011) Multi-center feasibility study evaluating recruitment, variability in risk factors and biomarkers for a diet and cancer cohort in India. BMC Public Health 11:405
Gunter, Marc J; Cross, Amanda J; Huang, Wen-Yi et al. (2011) A prospective evaluation of C-reactive protein levels and colorectal adenoma development. Cancer Epidemiol Biomarkers Prev 20:537-44

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