Case-control studies of cancers of the bladder, kidney, prostate, pancreas, esophagus, stomach, lung, brain, and head and neck, as well as non-Hodgkins lymphoma and multiple myeloma, are in progress. Two large case-control studies of kidney cancer are ongoing in the United States and in Eastern Europe to identify risk factors for kidney cancer. Results from the U.S. study suggest that a family history of kidney cancer is associated with a doubling of kidney cancer risk. These findings were similar in Caucasians and African Americans. In contrast, chronic hepatitis C virus infection was not related to kidney cancer risk in the Swedish population. In a cohort study of Chinese women, family history of colorectal cancer was associated with a tripling of colorectal cancer risk. In a pooled analysis of data from 10 case-control studies and two cohort studies, cigarette smoking was associated with increased risks of adenocarcinoma of the esophagus and esophagogastric junction in white men and women. Moreover, smoking cessation was shown to be associated with reduced risks of these sites. In a case-control study of gallbladder cancer in Shanghai, high parity, younger age at first birth, and late age at menarche were associated with increased risk, particularly among women with biliary stones. In addition, among participants who smoked and drank alcohol, a history of gastric or duodenal ulcers was associated with an excess of gallbladder cancer, supporting a role for inflammation in the etiology of gallbladder cancer. In a pooled analysis of data from eight case-control studies, sexual behaviors were associated with risk of cancer of the head and neck subsites that have previously been associated with HPV infection. In a second pooled analysis of 13 case-control studies, cessation of tobacco smoking and cessation of alcohol drinking appeared to reduce risk of head and neck cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Division of Cancer Epidemiology and Genetics
Zip Code
Bassig, Bryan A; Au, Wing-Yan; Mang, Oscar et al. (2016) Subtype-specific incidence rates of lymphoid malignancies in Hong Kong compared to the United States, 2001-2010. Cancer Epidemiol 42:15-23
Hofmann, Jonathan N; Birmann, Brenda M; Teras, Lauren R et al. (2016) Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals. Cancer Res 76:1935-41
Hofmann, Jonathan N; Corley, Douglas A; Zhao, Wei K et al. (2015) Chronic kidney disease and risk of renal cell carcinoma: differences by race. Epidemiology 26:59-67
Dellavalle, Curt T; Xiao, Qian; Yang, Gong et al. (2014) Dietary nitrate and nitrite intake and risk of colorectal cancer in the Shanghai Women's Health Study. Int J Cancer 134:2917-26
Shuch, Brian; Hofmann, Jonathan N; Merino, Maria J et al. (2014) Pathologic validation of renal cell carcinoma histology in the Surveillance, Epidemiology, and End Results program. Urol Oncol 32:23.e9-13
Hofmann, Jonathan N; Hutchinson, Amy A; Cawthon, Richard et al. (2014) Telomere length varies by DNA extraction method: implications for epidemiologic research-letter. Cancer Epidemiol Biomarkers Prev 23:1129-30
Purdue, Mark P; Ye, Yuanqing; Wang, Zhaoming et al. (2014) A genome-wide association study of renal cell carcinoma among African Americans. Cancer Epidemiol Biomarkers Prev 23:209-14
Perrotta, Carla; Kleefeld, Silke; Staines, Anthony et al. (2013) Multiple myeloma and occupation: a pooled analysis by the International Multiple Myeloma Consortium. Cancer Epidemiol 37:300-5
Olson, Sara H; Hsu, Meier; Satagopan, Jaya M et al. (2013) Allergies and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium. Am J Epidemiol 178:691-700
Bosetti, C; Lucenteforte, E; Silverman, D T et al. (2012) Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). Ann Oncol 23:1880-8

Showing the most recent 10 out of 29 publications