Infection, immune disturbances, and inflammation overlap in the ways that they damage tissues and promote development of cancer. Major studies under this project include the HIV/AIDS Cancer Match Study and Transplant Cancer Match Study, which link population-based registries of HIV infected people and transplant recipients to cancer registries in the U.S. Additional studies characterize risk factors for specific cancers in these immunosuppressed populations. Risk of non-Hodgkin lymphoma and lung cancer is elevated in immunosuppressed populations. Other cancers of interest, because they are associated with HIV or organ transplant, include Kaposi sarcoma, liver cancer, cancers related to human papillomavirus (such as cervical cancer and anal cancer), Hodgkin lymphoma, melanoma, non-melanoma skin cancers, kidney cancer, and multiple myeloma. Some studies under this project address the role of chronic infections, immune disturbance, and inflammation in these and other cancers. One study under this project is a case-control study of GB virus C and non-Hodgkin lymphoma. Other studies, which focus on cancer risk in the elderly, involve analyses of linked SEER Medicare registry data.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010150-12
Application #
8349571
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2011
Total Cost
$911,869
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Engels, E A (2017) Cancer in Solid Organ Transplant Recipients: There Is Still Much to Learn and Do. Am J Transplant 17:1967-1969
Yanik, Elizabeth L; Pfeiffer, Ruth M; Freedman, D Michal et al. (2017) Spectrum of Immune-Related Conditions Associated with Risk of Keratinocyte Cancers among Elderly Adults in the United States. Cancer Epidemiol Biomarkers Prev 26:998-1007
Yanik, Elizabeth L; Shiels, Meredith S; Smith, Jodi M et al. (2017) Contribution of solid organ transplant recipients to the pediatric non-hodgkin lymphoma burden in the United States. Cancer 123:4663-4671
Shiels, Meredith S; Chernyavskiy, Pavel; Anderson, William F et al. (2017) Trends in premature mortality in the USA by sex, race, and ethnicity from 1999 to 2014: an analysis of death certificate data. Lancet 389:1043-1054
Van Dyke, Alison L; Lang Kuhs, Krystle A; Shiels, Meredith S et al. (2017) Associations between self-reported diabetes and 78 circulating markers of inflammation, immunity, and metabolism among adults in the United States. PLoS One 12:e0182359
Hernández-Ramírez, Raúl U; Shiels, Meredith S; Dubrow, Robert et al. (2017) Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. Lancet HIV 4:e495-e504
Shiels, Meredith S; Engels, Eric A (2017) Evolving epidemiology of HIV-associated malignancies. Curr Opin HIV AIDS 12:6-11
Agerbaek, Mette Ø; Pereira, Marina A; Clausen, Thomas M et al. (2017) Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration. Int J Cancer 140:1597-1608
Howlader, Nadia; Mariotto, Angela B; Besson, Caroline et al. (2017) Cancer-specific mortality, cure fraction, and noncancer causes of death among diffuse large B-cell lymphoma patients in the immunochemotherapy era. Cancer 123:3326-3334
Dubrow, Robert; Qin, Li; Lin, Haiqun et al. (2017) Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. J Acquir Immune Defic Syndr 75:382-390

Showing the most recent 10 out of 144 publications