The goals will be achieved by a) evaluating obesity, energy balance, and physcial activity in relation to cancer incidence and survival;b) Improving assessment of energy intake, output, and body phenotype;c) Evaluating biomarkers to determine mechanisms including inflammatory cytokines (CRP, IL-6, TNF-alpha), growth factors and their major binding proteins (IGF-1 and IGFBP-3), steroid hormones (testosterone, estrogen, SHBG) in relation to cancer and intermediate outs comes such as weight loss and weight gain d) evaluate novel such as metabolomics in assessing obesity, energy balance, and physical activity and body phenotype and in relation to cancer risk. Although this project is for all cancer, its particular cancer includes breast, colorectal, and pancreatic cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010197-07
Application #
8763643
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2013
Total Cost
$749,585
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Xiao, Qian; Moore, Steven C; Keadle, Sarah K et al. (2016) Objectively measured physical activity and plasma metabolomics in the Shanghai Physical Activity Study. Int J Epidemiol :
Xiao, Qian; Signorello, Lisa B; Brinton, Louise A et al. (2016) Sleep duration and breast cancer risk among black and white women. Sleep Med 20:25-9
Starling, Anne P; Engel, Lawrence S; Calafat, Antonia M et al. (2015) Predictors and long-term reproducibility of urinary phthalate metabolites in middle-aged men and women living in urban Shanghai. Environ Int 84:94-106
Gennuso, Keith P; Matthews, Charles E; Colbert, Lisa H (2015) Reliability and Validity of 2 Self-Report Measures to Assess Sedentary Behavior in Older Adults. J Phys Act Health 12:727-32
Matthews, Charles E; Moore, Steven C; Sampson, Joshua et al. (2015) Mortality Benefits for Replacing Sitting Time with Different Physical Activities. Med Sci Sports Exerc 47:1833-40
Arem, Hannah; Matthews, Charles E; Lee, I-Min (2015) Physical Activity Is Key for Successful Aging-Reply: Even a Little Is Good. JAMA Intern Med 175:1863
Glenn, Kimberly R; Slaughter, James C; Fowke, Jay H et al. (2015) Physical activity, sedentary behavior and all-cause mortality among blacks and whites with diabetes. Ann Epidemiol 25:649-55
Arem, Hannah; Moore, Steven C; Patel, Alpa et al. (2015) Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med 175:959-67
Keadle, Sarah K; Moore, Steven C; Sampson, Joshua N et al. (2015) Causes of Death Associated With Prolonged TV Viewing: NIH-AARP Diet and Health Study. Am J Prev Med 49:811-21
Guertin, Kristin A; Loftfield, Erikka; Boca, Simina M et al. (2015) Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer. Am J Clin Nutr 101:1000-11

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