We investigate dietary factors in cohort studies and nutrition related biomarkers in nested case controls studies within the PLCO screeening trial cohort. The dietary factors have included glycemic index and folate. Biomarkers studies have included vitamin D, and insulin like growth factors and insulin resistance factors. PLCO has also participated in the VDPP. Thus far the studies for vitamin D, the Vitamin D Pooling Project for Rare Cancers , the IGF-1 axis biomarker studies and the folate and glycemic index dietary intake studies have completed and published.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010202-05
Application #
8763648
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2013
Total Cost
$285,529
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Stolzenberg-Solomon, Rachael Z; Newton, Christina C; Silverman, Debra T et al. (2015) Circulating Leptin and Risk of Pancreatic Cancer: A Pooled Analysis From 3 Cohorts. Am J Epidemiol 182:187-97
Piper, Marina R; Freedman, D Michal; Robien, Kim et al. (2015) Vitamin D-binding protein and pancreatic cancer: a nested case-control study. Am J Clin Nutr 101:1206-15
Olson, Sara H; Hsu, Meier; Wiemels, Joseph L et al. (2014) Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 23:1414-20
Arem, H; Bobe, G; Sampson, J et al. (2013) Flavonoid intake and risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study Cohort. Br J Cancer 108:1168-72
Brock, Kaye E; Huang, Wen-Yi; Fraser, David R et al. (2011) Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Br J Nutr 106:339-44
Douglas, Jason B; Silverman, Debra T; Weinstein, Stephanie J et al. (2011) Serum C-reactive protein and risk of pancreatic cancer in two nested, case-control studies. Cancer Epidemiol Biomarkers Prev 20:359-69
Douglas, Jason B; Silverman, Debra T; Pollak, Michael N et al. (2010) Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 19:2298-306
Meinhold, Cari L; Dodd, Kevin W; Jiao, Li et al. (2010) Available carbohydrates, glycemic load, and pancreatic cancer: is there a link? Am J Epidemiol 171:1174-82
Oaks, Brietta M; Dodd, Kevin W; Meinhold, Cari L et al. (2010) Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr 91:449-55