Cervical cancer etiology is better understood than the origins of most major malignancies. Within the Division of Cancer Epidemiology and Genetics, several groups continue to study the most interesting and important research topics. In the HPV Guanacaste Study, remaining topics in natural history of the causal virus (human papillomavirus, HPV) are the focus. The unusually high prevalence of HPV in sub Saharan Africa was another focus in the recently completed Nigeria Project Itoju. The now completed Portland study assessed the risk of cervical neoplasia in the 16 years following a single baseline HPV test and cytologic smear.Cervical Visualization Project: In this set of studies, HPV natural history is assessed visually (using a web-based open-source software system developed with the National Library of Medicine), microscopically (cytology and histology) and using a variety of molecular biomarkers. HPV Genome Project. Viral genomic studies are designed to determine why certain types of HPV, if persistent, are extremely powerful carcinogens (acquired genetic syndromes with high penetrance) while related HPV types are not. In the HPV Methylation Project, we are exploring the epigenetic changes in HPV and host genes in relationship to risk of HPV persistence, progression to CIN3, and invasion.The Persistence and Progression (PaP) cohort is a collaboration with Kaiser Permanente Northern California. More than 40,000 women with dual testing with positive HPV DNA assays and cytology are being followed for outcome.The New Mexico Pap Registry is a collaboration with Dr. Cosette Wheeler at U. New Mexico, consisting of a statewide surveillance of cytology and histology outcomes. In a subset, HPV testing is available. The goal eventually is to monitor the impact of HPV vaccination on cervical screening.HPV Cervical Cancer Risk Prediction. This study involves translation of what we have learned about HPV and cervical carcinogenesis into clnical guidelines, particularly via risk prediction models. The main source of data is Kaiser Permanente Northern California, with its decade-long experience with HPV and Pap cotesting.This research project is human population based, and both etiologic and translational.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Division of Cancer Epidemiology and Genetics
Zip Code
Zhao, Fang-Hui; Hu, Shang-Ying; Zhang, Qian et al. (2016) Risk assessment to guide cervical screening strategies in a large Chinese population. Int J Cancer 138:2639-47
Frimer, Marina; Sun, Chang; McAndrew, Thomas et al. (2015) HPV16 CpG methyl-haplotypes are associated with cervix precancer and cancer in the Guanacaste natural history study. Gynecol Oncol 138:94-100
Gage, Julia C; Katki, Hormuzd A; Schiffman, Mark et al. (2015) Age-stratified 5-year risks of cervical precancer among women with enrollment and newly detected HPV infection. Int J Cancer 136:1665-71
Mirabello, Lisa; Frimer, Marina; Harari, Ariana et al. (2015) HPV16 methyl-haplotypes determined by a novel next-generation sequencing method are associated with cervical precancer. Int J Cancer 136:E146-53
Schiffman, Mark; Wentzensen, Nicolas (2015) Transitioning to a new era in cervical cancer screening. Gynecol Oncol 136:175-7
Schiffman, Mark; Boyle, Sean; Raine-Bennett, Tina et al. (2015) The Role of Human Papillomavirus Genotyping in Cervical Cancer Screening: A Large-Scale Evaluation of the cobas HPV Test. Cancer Epidemiol Biomarkers Prev 24:1304-10
Schiffman, M; Burk, R D; Boyle, S et al. (2015) A study of genotyping for management of human papillomavirus-positive, cytology-negative cervical screening results. J Clin Microbiol 53:52-9
Schiffman, Mark; Vaughan, Laurence M; Raine-Bennett, Tina R et al. (2015) A study of HPV typing for the management of HPV-positive ASC-US cervical cytologic results. Gynecol Oncol 138:573-8
Jemal, Ahmedin; Simard, Edgar P; Dorell, Christina et al. (2013) Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst 105:175-201
Ajenifuja, Kayode Olusegun; Gage, Julia C; Adepiti, Akinfolarin C et al. (2013) A population-based study of visual inspection with acetic acid (VIA) for cervical screening in rural Nigeria. Int J Gynecol Cancer 23:507-12

Showing the most recent 10 out of 27 publications