Most noncardia gastric cancers are attributable to chronic mucosal inflammation due to Helicobacter pylori infection and some tumors also contain monoclonal Epstein-Barr virus (EBV). We are studying the descriptive epidemiology of this disease and the roles of EBV infection and of inflammation gene polymorphisms in its etiology and outcomes. We are studying clonal expansion of lymphocytes as a potential precursor of non-Hodgkin's lymphoma in HIV infection and the general population, using multiple prospective cohorts with banked peripheral blood cells. IIB studies have implicated cytokine signaling dysregulation as an important etiologic factor for AIDS-related lymphoma. Both elevated blood levels as well as genetic variation in these pathways are predictive of subsequent lymphoma risk. Despite marked advances in antiretroviral therapy, cancer continues to be a major source of morbidity in AIDS.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010212-03
Application #
8565467
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2012
Total Cost
$128,283
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Rabkin, Charles S; Goedert, James J (2017) Chronic Hepatitis and Non-Hodgkin Lymphoma Among People With HIV: Implications for Screening, Treatment, and Prevention. Ann Intern Med 166:69-70
Figueiredo, Ceu; Camargo, M C; Leite, Marina et al. (2017) Pathogenesis of Gastric Cancer: Genetics and Molecular Classification. Curr Top Microbiol Immunol 400:277-304
Miller, Halie K; Santo, Loredana; Camargo, M Constanza et al. (2017) Coxiella burnetii antibody seropositivity is not a risk factor for AIDS-related non-Hodgkin lymphoma. Blood 129:3262-3264
Leja, Marcis; Camargo, M Constanza; Polaka, Inese et al. (2017) Detection of gastric atrophy by circulating pepsinogens: A comparison of three assays. Helicobacter 22:
Breyer, Benjamin N; Huang, Wen-Yi; Rabkin, Charles S et al. (2016) Sexually transmitted infections, benign prostatic hyperplasia and lower urinary tract symptom-related outcomes: results from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. BJU Int 117:145-54
Derks, Sarah; Liao, Xiaoyun; Chiaravalli, Anna M et al. (2016) Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers. Oncotarget 7:32925-32
Goedert, James J; Hosgood, H Dean; Biggar, Robert J et al. (2016) Screening for Cancer in Persons Living with HIV Infection. Trends Cancer 2:416-428
Camargo, M Constanza; Bowlby, Reanne; Chu, Andy et al. (2016) Validation and calibration of next-generation sequencing to identify Epstein-Barr virus-positive gastric cancer in The Cancer Genome Atlas. Gastric Cancer 19:676-81
Camargo, M Constanza; Kim, Kyoung-Mee; Matsuo, Keitaro et al. (2016) Anti-Helicobacter pylori Antibody Profiles in Epstein-Barr virus (EBV)-Positive and EBV-Negative Gastric Cancer. Helicobacter 21:153-7
Basavaraju, Umesh; Shebl, Fatma M; Palmer, Andrew J et al. (2015) Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland. Eur J Cancer Prev 24:296-304

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