Most noncardia gastric cancers are attributable to chronic mucosal inflammation due to Helicobacter pylori infection and some tumors also contain monoclonal Epstein-Barr virus (EBV). We are studying the descriptive epidemiology of this disease and the roles of EBV infection and of inflammation gene polymorphisms in its etiology and outcomes. We are studying clonal expansion of lymphocytes as a potential precursor of non-Hodgkin's lymphoma in HIV infection and the general population, using multiple prospective cohorts with banked peripheral blood cells. IIB studies have implicated cytokine signaling dysregulation as an important etiologic factor for AIDS-related lymphoma. Both elevated blood levels as well as genetic variation in these pathways are predictive of subsequent lymphoma risk. Despite marked advances in antiretroviral therapy, cancer continues to be a major source of morbidity in AIDS.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010212-04
Application #
8763654
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$135,000
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Liu, Yang; Sethi, Nilay S; Hinoue, Toshinori et al. (2018) Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell 33:721-735.e8
Song, Minkyo; Camargo, M Constanza; Weinstein, Stephanie J et al. (2018) Family history of cancer in first-degree relatives and risk of gastric cancer and its precursors in a Western population. Gastric Cancer 21:729-737
Thorsson, V├ęsteinn; Gibbs, David L; Brown, Scott D et al. (2018) The Immune Landscape of Cancer. Immunity 48:812-830.e14
Song, M; Camargo, M C; Weinstein, S J et al. (2018) Serum pepsinogen 1 and anti-Helicobacter pylori IgG antibodies as predictors of gastric cancer risk in Finnish males. Aliment Pharmacol Ther 47:494-503
Wong, Cherise; Gange, Stephen J; Moore, Richard D et al. (2018) Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States. Clin Infect Dis 66:1230-1238
Lunn, Ruth M; Jahnke, Gloria D; Rabkin, Charles S (2017) Tumour virus epidemiology. Philos Trans R Soc Lond B Biol Sci 372:
Leja, Marcis; Camargo, M Constanza; Polaka, Inese et al. (2017) Detection of gastric atrophy by circulating pepsinogens: A comparison of three assays. Helicobacter 22:
Rabkin, Charles S; Goedert, James J (2017) Chronic Hepatitis and Non-Hodgkin Lymphoma Among People With HIV: Implications for Screening, Treatment, and Prevention. Ann Intern Med 166:69-70
Figueiredo, Ceu; Camargo, M C; Leite, Marina et al. (2017) Pathogenesis of Gastric Cancer: Genetics and Molecular Classification. Curr Top Microbiol Immunol 400:277-304
Miller, Halie K; Santo, Loredana; Camargo, M Constanza et al. (2017) Coxiella burnetii antibody seropositivity is not a risk factor for AIDS-related non-Hodgkin lymphoma. Blood 129:3262-3264

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