Most noncardia gastric cancers are attributable to chronic mucosal inflammation due to Helicobacter pylori infection and some tumors also contain monoclonal Epstein-Barr virus (EBV). We are studying the descriptive epidemiology of this disease and the roles of EBV infection and of inflammation gene polymorphisms in its etiology and outcomes. We are studying clonal expansion of lymphocytes as a potential precursor of non-Hodgkin's lymphoma in HIV infection and the general population, using multiple prospective cohorts with banked peripheral blood cells. IIB studies have implicated cytokine signaling dysregulation as an important etiologic factor for AIDS-related lymphoma. Both elevated blood levels as well as genetic variation in these pathways are predictive of subsequent lymphoma risk. Despite marked advances in antiretroviral therapy, cancer continues to be a major source of morbidity in AIDS.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010212-04
Application #
8763654
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$135,000
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Camargo, M Constanza; García, Apolinaria; Riquelme, Arnoldo et al. (2014) The problem of Helicobacter pylori resistance to antibiotics: a systematic review in Latin America. Am J Gastroenterol 109:485-95
Camargo, M Constanza; Koriyama, Chihaya; Matsuo, Keitaro et al. (2014) Case-case comparison of smoking and alcohol risk associations with Epstein-Barr virus-positive gastric cancer. Int J Cancer 134:948-53
Bonequi, Patricia; Meneses-González, Fernando; Correa, Pelayo et al. (2013) Risk factors for gastric cancer in Latin America: a meta-analysis. Cancer Causes Control 24:217-31