This project includes two studies: 1) the Shanghai Biliary Tract Cancer Study, 2)the Chile Gallbladder Cancer Study. These studies complement each other and will provide unique insight into the etiology of biliary tract cancer. The Shanghai Study includes more than 3,000 subjects, including over 600 biliary tract cancer patients, 900 gallstone patients, and 1,000 healthy controls randomly selected from the population. A structured questionnaire was used to elicit information on epidemiologic risk factors, including smoking, drinking, diet, medical history, and reproductive factors. The study had a strong biochemical and molecular component with an extensive collection of biological samples, including serum, DNA, gallstones, bile, and tissue samples. The Chile Gallbladder Cancer Study includes a pilot study of 120 subjects. The full-scale study will include 4000 cases of gallbladder cancer and 4000 controls enrolled from 12 locations in Chile, which has the highest risk of gallbladder cancer in the world. Similar to the Shanghai Study, the Chile Study will incorporate extensive biospecimen collection. It will complement the Shanghai Study by allowing replication and validation of previous findings, as well as evaluation of unique exposure (i.e. salmonella typhi and heavy metals).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010218-02
Application #
8565473
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2012
Total Cost
$623,599
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Koshiol, Jill; Gao, Yu-Tang; Dean, Michael et al. (2017) Association of Aflatoxin and Gallbladder Cancer. Gastroenterology 153:488-494.e1
Koshiol, Jill; Wozniak, Aniela; Cook, Paz et al. (2016) Salmonella enterica serovar Typhi and gallbladder cancer: a case-control study and meta-analysis. Cancer Med 5:3310-3235
Van Dyke, Alison L; Kemp, Troy J; Corbel, Amanda F et al. (2016) Lipopolysaccharide-pathway proteins are associated with gallbladder cancer among adults in Shanghai, China with mediation by systemic inflammation. Ann Epidemiol 26:704-709
Ferreccio, Catterina; Roa, Juan Carlos; Bambs, Claudia et al. (2016) Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024. BMC Public Health 16:122
Koshiol, Jill; Castro, Felipe; Kemp, Troy J et al. (2016) Association of inflammatory and other immune markers with gallbladder cancer: Results from two independent case-control studies. Cytokine 83:217-225
Espinoza, Jaime A; Bizama, Carolina; GarcĂ­a, Patricia et al. (2016) The inflammatory inception of gallbladder cancer. Biochim Biophys Acta 1865:245-54
Nogueira, Leticia; Foerster, Claudia; Groopman, John et al. (2015) Association of aflatoxin with gallbladder cancer in Chile. JAMA 313:2075-7
Xu, Hong-Li; Hsing, Ann W; Koshiol, Jill et al. (2014) Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China. Meta Gene 2:418-426
Castro, Felipe A; Koshiol, Jill; Hsing, Ann W et al. (2012) Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China. BMC Cancer 12:468
Andreotti, Gabriella; Liu, Enju; Gao, Yu-Tang et al. (2011) Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation. Cancer Causes Control 22:1289-96

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